Literature DB >> 15121322

Technologies that make administration of vaccines safer.

C John Clements1, Gordon Larsen, Luis Jodar.   

Abstract

There is an ever-expanding technology that is aimed at making the administration of vaccines safer. Conventional ways of administering vaccines are being upgraded, modified or replaced by a wide variety of innovations. The paradigm of liquid vaccines, needles and syringes is slow to change, but already developments are occurring that will change for ever the way vaccines are administered and will improve the safety record of immunization. The oral route of vaccine administration has generally been thought of as safe, but until now only the polio vaccine has been widely used in this way. The conventional method of vaccine administration is by injection. Many ingenious devices have become available that now make injecting safer. Inventors are now looking imaginatively to alternative routes and technologies for delivering vaccines. Vaccines are generally manufactured to extremely high standards and rarely are shown to be the cause of safety issues. People remain the weakest safety link is vaccine administration. Technologies that bypasses the ability of man to make bad decisions or to behave incorrectly are of tremendous value. The vaccine world is in the middle of a radical re-think about how vaccines might best be administered. The presentation of the vaccine can be altered to fit new technologies such as powder jet guns, or skin patches. Even the conventional needle and syringe have evolved to much safer versions, and are set to continue this evolution. All this means even safer vaccines and their delivery.

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Year:  2004        PMID: 15121322     DOI: 10.1016/j.vaccine.2004.01.008

Source DB:  PubMed          Journal:  Vaccine        ISSN: 0264-410X            Impact factor:   3.641


  11 in total

1.  Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.

Authors:  William M Gwinn; Shaun M Kirwan; Sheena H Wang; Kathleen A Ashcraft; Neil L Sparks; Catherine R Doil; Tom G Tlusty; Leslie S Casey; Susan K Hollingshead; David E Briles; Richard S Dondero; Anthony J Hickey; W Michael Foster; Herman F Staats
Journal:  Vaccine       Date:  2010-08-17       Impact factor: 3.641

2.  Vaccine Presentation and Packaging Advisory Group: a forum for reaching consensus on vaccine product attributes.

Authors:  Osman David Mansoor; Debra Kristensen; Andrew Meek; Simona Zipursky; Olga Popova; Olga Popovaa; InderJit Sharma; Gisele Miranda; Jules Millogo; Heidi Lasher
Journal:  Bull World Health Organ       Date:  2012-11-05       Impact factor: 9.408

3.  Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches.

Authors:  Leonard Y Chu; Ling Ye; Ke Dong; Richard W Compans; Chinglai Yang; Mark R Prausnitz
Journal:  Pharm Res       Date:  2015-12-01       Impact factor: 4.200

Review 4.  Microneedle patches for vaccination in developing countries.

Authors:  Jaya Arya; Mark R Prausnitz
Journal:  J Control Release       Date:  2015-11-18       Impact factor: 9.776

5.  Acceptability and Feasibility of Delivering Pentavalent Vaccines in a Compact, Prefilled, Autodisable Device in Vietnam and Senegal.

Authors:  Elise Guillermet; Hamadou M Dicko; Le Thi Phuong Mai; Mamadou N'Diaye; Fatoumata Hane; Seydina Ousmane Ba; Khadidjatou Gomis; Nguyen Thi Thi Tho; Nguyen Thi Phuong Lien; Phan Dang Than; Tran Van Dinh; Philippe Jaillard; Bradford D Gessner; Anais Colombini
Journal:  PLoS One       Date:  2015-07-17       Impact factor: 3.240

6.  Development of thermostable lyophilized inactivated polio vaccine.

Authors:  Heleen Kraan; Paul van Herpen; Gideon Kersten; Jean-Pierre Amorij
Journal:  Pharm Res       Date:  2014-04-24       Impact factor: 4.200

Review 7.  The Influence of Vaccine on Febrile Seizure.

Authors:  Xin Li; Yang Lin; Gang Yao; Yicun Wang
Journal:  Curr Neuropharmacol       Date:  2018       Impact factor: 7.363

8.  Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers.

Authors:  Aleksandra Inic-Kanada; Marijana Stojanovic; Simone Schlacher; Elisabeth Stein; Sandra Belij-Rammerstorfer; Emilija Marinkovic; Ivana Lukic; Jacqueline Montanaro; Nadine Schuerer; Nora Bintner; Vesna Kovacevic-Jovanovic; Ognjen Krnjaja; Ulrike Beate Mayr; Werner Lubitz; Talin Barisani-Asenbauer
Journal:  PLoS One       Date:  2015-12-11       Impact factor: 3.240

9.  Immunogenicity and safety of measles-mumps-rubella vaccine delivered by disposable-syringe jet injector in India: A randomized, parallel group, non-inferiority trial.

Authors:  Ashish Bavdekar; Jitendra Oswal; Padmasani Venkat Ramanan; Chandrashekhar Aundhkar; P Venugopal; Dhananjay Kapse; Tara Miller; Sarah McGray; Darin Zehrung; Prasad S Kulkarni
Journal:  Vaccine       Date:  2018-02-01       Impact factor: 3.641

Review 10.  The safety of vaccines.

Authors:  Derek T O'Hagan; Rino Rappuoli
Journal:  Drug Discov Today       Date:  2004-10-01       Impact factor: 7.851

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