| Literature DB >> 15121306 |
Xuan-Yi Wang1, Zhiyi Xu, Xing Yao, Meiying Tian, Liangdi Zhou, Lifang He, Yumei Wen.
Abstract
The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared. Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed. In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months. The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15121306 DOI： 10.1016/j.vaccine.2003.11.007
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641