| Literature DB >> 15120936 |
Francis J Giles1, Julie M Vose, Kim-Anh Do, Marcella M Johnson, Taghi Manshouri, Gregory Bociek, Philip J Bierman, Susan M O'Brien, Hagop M Kantarjian, James O Armitage, Maher Albitar.
Abstract
Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.Entities:
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Year: 2004 PMID： 15120936 DOI： 10.1016/j.leukres.2003.11.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156