UNLABELLED: Infectious complications of the diabetic foot may be influenced by impaired renal function and by immunosuppression therapy. AIMS: To assess differences in microbial findings and resistance to antibiotics between transplant recipients, hemodialysis patients, and other patients with the diabetic foot. METHODS: 207 patients treated in the foot clinic for diabetic ulcers from 12/1998 to 12/1999 were included into this retrospective study. Patients were divided into three groups (transplant, dialysis, and other patients). Occurrence of individual bacterial species and resistance to antibiotics was compared between study groups. RESULTS: Study groups did not differ significantly in ulcer grades defined by the Wagner classification or in the mean number of pathogens per patient. The prevalence of individual microorganisms did not differ between the study groups. However, the study groups differed significantly in the occurrence of microbial resistance to antibiotics. Transplant patients had more frequently Staphylococcus aureus resistant to oxacillin (P<.01), imipenem (P<.01), co-trimoxazole (P<.01), Enterococcus species resistant to ampicillin (P<.01), piperacillin (P<.01), and dialysis patients had more frequently Pseudomonas species resistant to piperacillin (P<.05) and cefpirom (P<.05) in comparison with the other two groups. CONCLUSIONS: Transplant patients had significantly more resistant microorganisms in comparison with dialysis and other patients with the diabetic foot. Empiric antibiotic selection based on general population data should be modified in transplant patients with diabetic foot according to actual susceptibility to antibacterial drugs.
UNLABELLED: Infectious complications of the diabetic foot may be influenced by impaired renal function and by immunosuppression therapy. AIMS: To assess differences in microbial findings and resistance to antibiotics between transplant recipients, hemodialysis patients, and other patients with the diabetic foot. METHODS: 207 patients treated in the foot clinic for diabetic ulcers from 12/1998 to 12/1999 were included into this retrospective study. Patients were divided into three groups (transplant, dialysis, and other patients). Occurrence of individual bacterial species and resistance to antibiotics was compared between study groups. RESULTS: Study groups did not differ significantly in ulcer grades defined by the Wagner classification or in the mean number of pathogens per patient. The prevalence of individual microorganisms did not differ between the study groups. However, the study groups differed significantly in the occurrence of microbial resistance to antibiotics. Transplant patients had more frequently Staphylococcus aureus resistant to oxacillin (P<.01), imipenem (P<.01), co-trimoxazole (P<.01), Enterococcus species resistant to ampicillin (P<.01), piperacillin (P<.01), and dialysis patients had more frequently Pseudomonas species resistant to piperacillin (P<.05) and cefpirom (P<.05) in comparison with the other two groups. CONCLUSIONS: Transplant patients had significantly more resistant microorganisms in comparison with dialysis and other patients with the diabetic foot. Empiric antibiotic selection based on general population data should be modified in transplant patients with diabetic foot according to actual susceptibility to antibacterial drugs.
Authors: Vladimíra Fejfarová; Alexandra Jirkovská; Michal Dubský; Frances Game; Jana Vydláková; Alena Sekerková; Jana Franeková; Monika Kučerová; Ilja Stříž; Vladimír Petkov; Robert Bém; Veronika Wosková; Andrea Němcová; Jelena Skibová Journal: J Diabetes Res Date: 2016-12-05 Impact factor: 4.011
Authors: Vladimíra Fejfarová; Jaroslav Pavlů; Robert Bém; Veronika Wosková; Michal Dubský; Andrea Němcová; Alexandra Jirkovská; Bedřich Sixta; Karol Sutoris; Filip Thieme; David G Armstrong; Eliška Vrátná; Jitka Hazdrová; Věra Lánská Journal: J Diabetes Res Date: 2019-09-15 Impact factor: 4.011
Authors: Lingyan Meng; Nicholas Graves; Ruo Chen Du; Jia Yi Lee; Koy Min Chue; Nur Nabila Farhana Binte Taufiq Chong Ah Hoo; Nuraini Nazeha; Yi Zhen Ng; Keith Harding; Pei Ho Journal: Int Wound J Date: 2021-12-16 Impact factor: 3.099
Authors: L Prompers; N Schaper; J Apelqvist; M Edmonds; E Jude; D Mauricio; L Uccioli; V Urbancic; K Bakker; P Holstein; A Jirkovska; A Piaggesi; G Ragnarson-Tennvall; H Reike; M Spraul; K Van Acker; J Van Baal; F Van Merode; I Ferreira; M Huijberts Journal: Diabetologia Date: 2008-02-23 Impact factor: 10.122