OBJECTIVES: This study was undertaken to evaluate whether prenatal zinc supplementation affects maturation of fetal cardiac patterns. STUDY DESIGN: A randomized double-blind controlled trial among 242 low-income Peruvian women was performed. Beginning at 10 to 16 weeks' gestation, women received supplements containing 60 mg iron, 250 microg folic acid with or without 25 mg zinc. Fetal heart rate (mean FHR, variability [HRV], number of accelerations) and movements (number and amplitude of movement bouts, time spent moving) were electronically monitored monthly from 20 weeks' gestation. Developmental trends were evaluated by supplement type among 195 women who completed the trial and had no serious complications of pregnancy. RESULTS:Zinc supplementation was associated with lower FHR, greater number of accelerations, and greater HRV. Supplementation effects on HRV and accelerations were more pronounced after 28 weeks' gestation. No differences in motor activity were observed. CONCLUSION: Prenatal supplementation of zinc-deficient mothers may be beneficial to fetal neurobehavioral development.
RCT Entities:
OBJECTIVES: This study was undertaken to evaluate whether prenatal zinc supplementation affects maturation of fetal cardiac patterns. STUDY DESIGN: A randomized double-blind controlled trial among 242 low-income Peruvian women was performed. Beginning at 10 to 16 weeks' gestation, women received supplements containing 60 mg iron, 250 microg folic acid with or without 25 mg zinc. Fetal heart rate (mean FHR, variability [HRV], number of accelerations) and movements (number and amplitude of movement bouts, time spent moving) were electronically monitored monthly from 20 weeks' gestation. Developmental trends were evaluated by supplement type among 195 women who completed the trial and had no serious complications of pregnancy. RESULTS: Zinc supplementation was associated with lower FHR, greater number of accelerations, and greater HRV. Supplementation effects on HRV and accelerations were more pronounced after 28 weeks' gestation. No differences in motor activity were observed. CONCLUSION: Prenatal supplementation of zinc-deficient mothers may be beneficial to fetal neurobehavioral development.
Authors: Laura E Caulfield; Diane L Putnick; Nelly Zavaleta; Fabiola Lazarte; Carla Albornoz; Ping Chen; Janet A Dipietro; Marc H Bornstein Journal: Am J Clin Nutr Date: 2010-05-19 Impact factor: 7.045
Authors: M L Mispireta; L E Caulfield; N Zavaleta; M Merialdi; D L Putnick; M H Bornstein; J A DiPietro Journal: J Dev Orig Health Dis Date: 2016-10-17 Impact factor: 2.401
Authors: Laura E Caulfield; Nelly Zavaleta; Ping Chen; Fabiola Lazarte; Carla Albornoz; Diane L Putnick; Marc H Bornstein; Janet A DiPietro Journal: J Nutr Date: 2010-12-22 Impact factor: 4.798
Authors: Laura E Caulfield; Carmen M Donangelo; Ping Chen; Jorge Junco; Mario Merialdi; Nelly Zavaleta Journal: Nutrition Date: 2008-07-07 Impact factor: 4.008
Authors: Marisa N Spann; Jennifer Smerling; Hanna Gustafsson; Sophie Foss; Margaret Altemus; Catherine Monk Journal: Early Hum Dev Date: 2015-02-03 Impact factor: 2.079