| Literature DB >> 1511859 |
M Kirkova1, T Kassabova, E Russanov.
Abstract
1. The in vivo effects of indomethacin on the activity of antioxidant enzymes and on lipid peroxidation in erythrocytes, liver and small intestines of rats were examined. 2. The activity of the enzymes studied increased or remained unchanged depending on the preparation and model used: treatment with "therapeutic" or "ulcerogenic" dose of indomethacin. 3. Indomethacin inhibited lipid peroxidation in the liver but not in the erythrocytes. 4. The results suggest that the stimulation of antioxidant enzymes, probably through in vivo formed metal complexes, is an alternative mechanism of the antiinflammatory action of indomethacin.Entities:
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Year: 1992 PMID： 1511859 DOI： 10.1016/0306-3623(92)90119-5
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623