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Literature DB >> 15117886

TGF-beta signaling and the fibrotic response.

Abstract

The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic disease, it is essential to appreciate how matrix deposition is normally controlled and how this process is dysregulated in fibrogenesis. This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF, CCN2), and ED-A fibronectin (ED-A FN) and the antifibrotic proteins tumor necrosis factor-alpha (TNF-alpha) and gamma-interferon (IFN-gamma).

Entities: Disease Gene

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Year: 2004 PMID： 15117886 DOI： 10.1096/fj.03-1273rev

Source DB: PubMed Journal: FASEB J ISSN： 0892-6638 Impact factor: 5.191

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Cited

846 in total

10. Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A.

Authors: Loka R K Penke; Steven K Huang; Eric S White; Marc Peters-Golden
Journal: J Biol Chem Date: 2014-05-05 Impact factor: 5.157

TGF-beta signaling and the fibrotic response.

1. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation.

2. Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications.

Review 3. Extracellular matrix proteins in hemostasis and thrombosis.

4. TGF-β1 enhances contractility in engineered skeletal muscle.

5. Role of immune cells and inflammatory cytokines in regulation of fibrosis around silicone expander implants.

6. Biosimulation of inflammation and healing in surgically injured vocal folds.

7. Blocking IKKα expression inhibits prostate cancer invasiveness.

8. Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease.

9. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

10. Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A.