Literature DB >> 1511741

Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate.

T Dyrks1, E Dyrks, C Masters, K Beyreuther.   

Abstract

Previously we have shown that the COOH-terminal fragment (A4CT) of the Alzheimer amyloid protein precursor (APP), which at the NH2-terminus carries the sequence of the amyloid beta A4 protein, forms highly insoluble aggregates [EMBO J. (1988) 7, 949-957]. Here we report that aggregation is prevented if A4CT is expressed in vitro with a signal sequence at the NH2-terminus (SPA4CT) under conditions which allow membrane insertion. Aggregates from SPA4CT are obtained after removal of membranes by chloroform/methanol extraction or heating.

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Year:  1992        PMID： 1511741     DOI： 10.1016/0014-5793(92)80730-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.

Authors:  Stefan F Lichtenthaler; Dirk Beher; Heike S Grimm; Rong Wang; Mark S Shearman; Colin L Masters; Konrad Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

2.  Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.

Authors:  Lisa-Marie Munter; Anne Botev; Luise Richter; Peter W Hildebrand; Veit Althoff; Christoph Weise; Daniela Kaden; Gerd Multhaup
Journal:  J Biol Chem       Date:  2010-05-07       Impact factor: 5.157

3.  Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.

Authors:  Vanessa Schmidt; Katharina Baum; Angelyn Lao; Katja Rateitschak; Yvonne Schmitz; Anke Teichmann; Burkhard Wiesner; Claus Munck Petersen; Anders Nykjaer; Jana Wolf; Olaf Wolkenhauer; Thomas E Willnow
Journal:  EMBO J       Date:  2011-10-11       Impact factor: 11.598

4.  Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.

Authors:  Vivek Venkataramani; Christian Rossner; Lara Iffland; Stefan Schweyer; Irfan Y Tamboli; Jochen Walter; Oliver Wirths; Thomas A Bayer
Journal:  J Biol Chem       Date:  2010-02-09       Impact factor: 5.157

5.  Inhibition of beta A4 production by specific modulation of beta-secretase activity.

Authors:  B Urmoneit; C Reinsch; J Turner; C Czech; K Beyreuther; T Dyrks
Journal:  J Mol Neurosci       Date:  1995       Impact factor: 3.444

6.  Expression of the C terminus of the amyloid precursor protein alters growth factor responsiveness in stably transfected PC12 cells.

Authors:  F A Sandhu; Y Kim; K A Lapan; M Salim; V Aliuddin; S B Zain
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-05       Impact factor: 11.205

7.  GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Authors:  Lisa-Marie Munter; Philipp Voigt; Anja Harmeier; Daniela Kaden; Kay E Gottschalk; Christoph Weise; Rüdiger Pipkorn; Michael Schaefer; Dieter Langosch; Gerd Multhaup
Journal:  EMBO J       Date:  2007-03-01       Impact factor: 11.598

8.  Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.

Authors:  A Fossgreen; B Brückner; C Czech; C L Masters; K Beyreuther; R Paro
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

9.  Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing.

Authors:  Caroline Evrard; Pascal Kienlen-Campard; Mathilde Coevoet; Rémi Opsomer; Bernadette Tasiaux; Patricia Melnyk; Jean-Noël Octave; Luc Buée; Nicolas Sergeant; Valérie Vingtdeux
Journal:  Front Cell Neurosci       Date:  2018-11-22       Impact factor: 5.505
  9 in total

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