Literature DB >> 15116296

Phagosomal acidification is not a prerequisite for intracellular multiplication of Legionella pneumophila in human monocytes.

Hagen Wieland1, Friedrich Goetz, Birgid Neumeister.   

Abstract

Legionella pneumophila is able to multiply in a variety of eukaryotic cells. Contradictory results have been published on the significance of phagosomal acidification in the intracellular multiplication of Legionella species in monocytes. Therefore, we analyzed the phagosomal pH values in 2 different types of human monocytes throughout the intracellular-replication cycles of 2 Legionella species that have different rates of intracellular multiplication. Our results show that phagosomal acidification is not a prerequisite for intracellular replication of Legionella pneumophila in human monocytes.

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Year:  2004        PMID： 15116296     DOI： 10.1086/382894

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  13 in total

Review 1.  Molecular pathogenesis of infections caused by Legionella pneumophila.

Authors:  Hayley J Newton; Desmond K Y Ang; Ian R van Driel; Elizabeth L Hartland
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

2.  Cysteine metabolism in Legionella pneumophila: characterization of an L-cystine-utilizing mutant.

Authors:  Fanny Ewann; Paul S Hoffman
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

Review 3.  Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.

Authors:  Ronald S Flannagan; Gabriela Cosío; Sergio Grinstein
Journal:  Nat Rev Microbiol       Date:  2009-05       Impact factor: 60.633

4.  Passage through Tetrahymena tropicalis triggers a rapid morphological differentiation in Legionella pneumophila.

Authors:  Gary Faulkner; Sharon G Berk; Elizabeth Garduño; Marco A Ortiz-Jiménez; Rafael A Garduño
Journal:  J Bacteriol       Date:  2008-09-19       Impact factor: 3.490

5.  Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection.

Authors:  John-Demian Sauer; Jeffrey G Shannon; Dale Howe; Stanley F Hayes; Michele S Swanson; Robert A Heinzen
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization.

Authors:  Audrey Chong; Celia A Lima; David S Allan; Gheyath K Nasrallah; Rafael A Garduño
Journal:  Infect Immun       Date:  2009-08-17       Impact factor: 3.441

7.  Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes.

Authors:  Esteban Fernandez-Moreira; Juergen H Helbig; Michele S Swanson
Journal:  Infect Immun       Date:  2006-06       Impact factor: 3.441

8.  Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway.

Authors:  Amrita D Joshi; Michele S Swanson
Journal:  Front Microbiol       Date:  2011-06-28       Impact factor: 5.640

Review 9.  The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.

Authors:  Ralph R Isberg; Tamara J O'Connor; Matthew Heidtman
Journal:  Nat Rev Microbiol       Date:  2008-11-17       Impact factor: 60.633

Review 10.  Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.

Authors:  Alexander W Ensminger; Ralph R Isberg
Journal:  Curr Opin Microbiol       Date:  2009-01-20       Impact factor: 7.934
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