Literature DB >> 15116186

DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA.

Torsten Bryld1, Torben Hojland, Jesper Wengel.   

Abstract

Incorporation of a novel pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA monomer into oligodeoxynucleotides leads to increased thermal stability of duplexes with DNA complements but reduced thermal stability of duplexes with RNA complements. This DNA-selective hybridization is explored for recognition of double-stranded DNA by a novel dual strand invasion approach.

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Year:  2004        PMID： 15116186     DOI： 10.1039/b402414a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes.

Authors:  Dale C Guenther; Raymond G Emehiser; Allison Inskeep; Saswata Karmakar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2020-06-24       Impact factor: 3.876

2.  High-affinity DNA targeting using readily accessible mimics of N2'-functionalized 2'-amino-α-L-LNA.

Authors:  Saswata Karmakar; Brooke A Anderson; Rie L Rathje; Sanne Andersen; Troels B Jensen; Poul Nielsen; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2011-08-09       Impact factor: 4.354

3.  Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers.

Authors:  Saswata Karmakar; Andreas S Madsen; Dale C Guenther; Bradley C Gibbons; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2014-08-21       Impact factor: 3.876

Review 4.  Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

Authors:  Michael E Østergaard; Patrick J Hrdlicka
Journal:  Chem Soc Rev       Date:  2011-04-13       Impact factor: 54.564

5.  Invader LNA: efficient targeting of short double stranded DNA.

Authors:  Sujay P Sau; T Santhosh Kumar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2010-03-04       Impact factor: 3.876

6.  Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

Authors:  T Santhosh Kumar; Andreas S Madsen; Michael E Østergaard; Sujay P Sau; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2009-02-06       Impact factor: 4.354

7.  Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides.

Authors:  Bradley A Didion; Saswata Karmakar; Dale C Guenther; Sujay P Sau; John P Verstegen; Patrick J Hrdlicka
Journal:  Chembiochem       Date:  2013-08-23       Impact factor: 3.164

8.  Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

Authors:  Sujay P Sau; Andreas S Madsen; Peter Podbevsek; Nicolai K Andersen; T Santhosh Kumar; Sanne Andersen; Rie L Rathje; Brooke A Anderson; Dale C Guenther; Saswata Karmakar; Pawan Kumar; Janez Plavec; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2013-09-25       Impact factor: 4.354

9.  Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA.

Authors:  Nicolai K Andersen; Brooke A Anderson; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2013-12-11       Impact factor: 4.354

10.  Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA.

Authors:  Shiva P Adhikari; Saswata Karmakar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2022-02-02       Impact factor: 3.876
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