BACKGROUND: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53. METHODS: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses. RESULTS: A positive statistically significant correlation was found between p27 and p21 expression (p<0.0001), but there was a negative correlation between COX-2 expression and both p27 (p = 0.001) and p21 (p<0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2. CONCLUSIONS: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
BACKGROUND: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53. METHODS: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses. RESULTS: A positive statistically significant correlation was found between p27 and p21 expression (p<0.0001), but there was a negative correlation between COX-2 expression and both p27 (p = 0.001) and p21 (p<0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2. CONCLUSIONS: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
Authors: T Hida; Y Yatabe; H Achiwa; H Muramatsu; K Kozaki; S Nakamura; M Ogawa; T Mitsudomi; T Sugiura; T Takahashi Journal: Cancer Res Date: 1998-09-01 Impact factor: 12.701
Authors: R Isik; M Metintas; A R Gibbs; S Metintas; B Jasani; U Oner; E Harmanci; S Demircan; S Işiksoy Journal: Respir Med Date: 2001-07 Impact factor: 3.415
Authors: M Bongiovanni; P Cassoni; P De Giuli; L Viberti; S Cappia; C Ivaldi; L Chiusa; G Bussolati Journal: Cancer Date: 2001-09-01 Impact factor: 6.860
Authors: A Baldi; A M Groeger; V Esposito; R Cassandro; G Tonini; T Battista; M P Di Marino; B Vincenzi; M Santini; A Angelini; R Rossiello; F Baldi; M G Paggi Journal: Thorax Date: 2002-04 Impact factor: 9.139
Authors: Joris D Veltman; Margaretha E H Lambers; Menno van Nimwegen; Rudi W Hendriks; Henk C Hoogsteden; Joachim G J V Aerts; Joost P J J Hegmans Journal: BMC Cancer Date: 2010-08-30 Impact factor: 4.430
Authors: Alfonso Baldi; Maria Teresa Piccolo; Maria Rosaria Boccellino; Aldo Donizetti; Irene Cardillo; Raffaele La Porta; Lucio Quagliuolo; Enrico P Spugnini; Francesca Cordero; Gennaro Citro; Massimo Menegozzo; Raffaele A Calogero; Stefania Crispi Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240
Authors: David W Greening; Hong Ji; Maoshan Chen; Bruce W S Robinson; Ian M Dick; Jenette Creaney; Richard J Simpson Journal: Sci Rep Date: 2016-09-08 Impact factor: 4.379