Literature DB >> 15115384

Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors.

Ki-Bong Oh1, Soo-Hwan Kim, Jaekwang Lee, Won-Jea Cho, Taeho Lee, Sanghee Kim.   

Abstract

On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.

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Year:  2004        PMID: 15115384     DOI: 10.1021/jm0498708

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  27 in total

Review 1.  Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria.

Authors:  Luciano A Marraffini; Andrea C Dedent; Olaf Schneewind
Journal:  Microbiol Mol Biol Rev       Date:  2006-03       Impact factor: 11.056

Review 2.  Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Authors:  Alejandro Beceiro; María Tomás; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

Review 3.  Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.

Authors:  Kathleen W Clancy; Jeffrey A Melvin; Dewey G McCafferty
Journal:  Biopolymers       Date:  2010       Impact factor: 2.505

4.  Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.

Authors:  Bala Chandra Chenna; Jason R King; Bidhan A Shinkre; Amanda L Glover; Aaron L Lucius; Sadanandan E Velu
Journal:  Eur J Med Chem       Date:  2010-05-20       Impact factor: 6.514

5.  Discovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme.

Authors:  Albert H Chan; Jeff Wereszczynski; Brendan R Amer; Sung Wook Yi; Michael E Jung; J Andrew McCammon; Robert T Clubb
Journal:  Chem Biol Drug Des       Date:  2013-10       Impact factor: 2.817

6.  Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.

Authors:  Konstantin V Kudryavtsev; Matthew L Bentley; Dewey G McCafferty
Journal:  Bioorg Med Chem       Date:  2009-02-13       Impact factor: 3.641

7.  Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase.

Authors:  Jie Zhang; Hongchuan Liu; Kongkai Zhu; Shouzhe Gong; Shaynoor Dramsi; Ya-Ting Wang; Jiafei Li; Feifei Chen; Ruihan Zhang; Lu Zhou; Lefu Lan; Hualiang Jiang; Olaf Schneewind; Cheng Luo; Cai-Guang Yang
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-02       Impact factor: 11.205

8.  Activation of inhibitors by sortase triggers irreversible modification of the active site.

Authors:  Anthony W Maresso; Ruiying Wu; Justin W Kern; Rongguang Zhang; Dorota Janik; Dominique M Missiakas; Mark-Eugene Duban; Andrzej Joachimiak; Olaf Schneewind
Journal:  J Biol Chem       Date:  2007-06-01       Impact factor: 5.157

Review 9.  Targeting Bacterial Sortases in Search of Anti-Virulence Therapies with Low Risk of Resistance Development.

Authors:  Georgiana Nitulescu; Denisa Margina; Anca Zanfirescu; Octavian Tudorel Olaru; George Mihai Nitulescu
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-30

10.  Taxifolin, an Inhibitor of Sortase A, Interferes With the Adhesion of Methicillin-Resistant Staphylococcal aureus.

Authors:  Li Wang; Guangming Wang; Han Qu; Kai Wang; Shisong Jing; Shuhan Guan; Liyan Su; Qianxue Li; Dacheng Wang
Journal:  Front Microbiol       Date:  2021-07-06       Impact factor: 5.640

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