Literature DB >> 15115126

Lack of in vitro effect of ivermectin on Plasmodium falciparum.

Peter Nasveld1, Bruce Russell, Barbara Kotecka, Karl Rieckmann.   

Abstract

The in vitro activity of ivermectin was assessed against the K1 isolate of Plasmodium falciparum. The mean IC50 and IC90 of ivermectin were 8.0 and 35.0 microg/ml, respectively. These results indicate that ivermectin has a very low activity against P. falciparum in vitro.

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Year:  2003        PMID： 15115126

Source DB:  PubMed          Journal:  Southeast Asian J Trop Med Public Health        ISSN： 0125-1562            Impact factor:   0.267


  10 in total

1.  Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro.

Authors:  Lais Pessanha de Carvalho; Thaisa Lucas Sandri; Edésio José Tenório de Melo; Rolf Fendel; Peter G Kremsner; Benjamin Mordmüller; Jana Held
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Searching for new antimalarial therapeutics amongst known drugs.

Authors:  Jennifer L Weisman; Ally P Liou; Anang A Shelat; Fred E Cohen; R Kiplin Guy; Joseph L DeRisi
Journal:  Chem Biol Drug Des       Date:  2006-06       Impact factor: 2.817

Review 3.  Ivermectin: a complimentary weapon against the spread of malaria?

Authors:  Haoues Alout; Brian D Foy
Journal:  Expert Rev Anti Infect Ther       Date:  2016-12-29       Impact factor: 5.091

4.  Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control.

Authors:  Kevin C Kobylinski; Haoues Alout; Brian D Foy; Archie Clements; Poom Adisakwattana; Brett E Swierczewski; Jason H Richardson
Journal:  Am J Trop Med Hyg       Date:  2014-07-28       Impact factor: 2.345

5.  Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets.

Authors:  Reagan M Mogire; Hoseah M Akala; Rosaline W Macharia; Dennis W Juma; Agnes C Cheruiyot; Ben Andagalu; Mathew L Brown; Hany A El-Shemy; Steven G Nyanjom
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240

6.  Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.

Authors:  Yudi T Pinilla; Stefanie C P Lopes; Vanderson S Sampaio; Francys S Andrade; Gisely C Melo; Alessandra S Orfanó; Nágila F C Secundino; Maria G V B Guerra; Marcus V G Lacerda; Kevin C Kobylinski; Karin S Escobedo-Vargas; Victor M López-Sifuentes; Craig A Stoops; G Christian Baldeviano; Joel Tarning; Gissella M Vasquez; Paulo F P Pimenta; Wuelton M Monteiro
Journal:  PLoS Negl Trop Dis       Date:  2018-02-14

7.  Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial.

Authors:  Brian D Foy; Haoues Alout; Jonathan A Seaman; Sangeeta Rao; Tereza Magalhaes; Martina Wade; Sunil Parikh; Dieudonné D Soma; André B Sagna; Florence Fournet; Hannah C Slater; Roland Bougma; François Drabo; Abdoulaye Diabaté; A Gafar V Coulidiaty; Nöel Rouamba; Roch K Dabiré
Journal:  Lancet       Date:  2019-03-14       Impact factor: 79.321

8.  Effects of combined drug treatments on Plasmodium falciparum: In vitro assays with doxycycline, ivermectin and efflux pump inhibitors.

Authors:  Riccardo Nodari; Yolanda Corbett; Ilaria Varotto-Boccazzi; Daniele Porretta; Donatella Taramelli; Sara Epis; Claudio Bandi
Journal:  PLoS One       Date:  2020-04-23       Impact factor: 3.240

9.  Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae.

Authors:  Kevin C Kobylinski; Brian D Foy; Jason H Richardson
Journal:  Malar J       Date:  2012-11-21       Impact factor: 2.979

10.  Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins.

Authors:  Raquel Azevedo; António M Mendes; Miguel Prudêncio
Journal:  Parasit Vectors       Date:  2019-11-21       Impact factor: 3.876
  10 in total

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