Literature DB >> 15114682

CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88.

Ling Lin1, Andrea J Gerth, Stanford L Peng.   

Abstract

Unmethylated CpG-containing DNA plays a critical role in immunity via the augmentation of Th1 but suppression of Th2 T cell responses. We describe here that CpG motifs also redirect isotype production by murine B cells to "Th1-like" Ig isotypes (IgG2a, IgG2b, and IgG3) while suppressing Th2 isotypes (IgG1 and IgE). Using genetically mutant B cells, we find that the IgG2a, IgG2b and IgG3 isotypes are transcriptionally regulated via the promotion of class-switching, in a manner critically dependent upon TLR9 and MyD88. Thus, CpG DNA redirects Ig isotype production by regulating the specificity of class-switch recombination.

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Year:  2004        PMID： 15114682     DOI： 10.1002/eji.200324736

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  52 in total

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Review 3.  Regulation of B-cell responses by Toll-like receptors.

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Review 4.  Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses.

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Review 7.  Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders.

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Review 8.  Toll-like receptors--sentries in the B-cell response.

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9.  Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF.

Authors:  Weifeng Xu; Paul A Santini; Allysia J Matthews; April Chiu; Alessandro Plebani; Bing He; Kang Chen; Andrea Cerutti
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10.  CpG-induced Th1-type response in the downmodulation of early development of allergy and inhibition of B7 expression on T cells of newborn mice.

Authors:  Cyro A de Brito; Ana E Fusaro; Jefferson R Victor; Paula O Rigato; Adriana L Goldoni; Bruno P Muniz; Alberto J S Duarte; Maria N Sato
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