BACKGROUND: University of Wisconsin (UW) solution is currently the standard preservation solution used for abdominal organ transplantation. This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation. METHODS: Between October 2002 and August 2003, 20 pancreas transplants were performed. Patients were divided into two groups: UW (n=10) and HTK (n=10). Donor and recipient demographics were similar in both groups. The mean cold ischemia time for both groups was 11 +/-3 hr. RESULTS: There was an anticipated difference between total preservative volumes used (HTK: 4.5 +/- 1.2 L vs. UW: 3.4 +/-0.8 L; P =0.03). Patient and graft survivals to date were 100% in both groups. Serum fasting blood glucose, peak amylase, and serial amylase levels remained comparable at all intervals posttransplantation. CONCLUSIONS: Within this range of cold ischemia time, UW and HTK demonstrate similar efficacy in pancreas preservation.
BACKGROUND: University of Wisconsin (UW) solution is currently the standard preservation solution used for abdominal organ transplantation. This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation. METHODS: Between October 2002 and August 2003, 20 pancreas transplants were performed. Patients were divided into two groups: UW (n=10) and HTK (n=10). Donor and recipient demographics were similar in both groups. The mean cold ischemia time for both groups was 11 +/-3 hr. RESULTS: There was an anticipated difference between total preservative volumes used (HTK: 4.5 +/- 1.2 L vs. UW: 3.4 +/-0.8 L; P =0.03). Patient and graft survivals to date were 100% in both groups. Serum fasting blood glucose, peak amylase, and serial amylase levels remained comparable at all intervals posttransplantation. CONCLUSIONS: Within this range of cold ischemia time, UW and HTK demonstrate similar efficacy in pancreas preservation.
Authors: Meirigeng Qi; Berit Løkensgard Strand; Yrr Mørch; Igor Lacík; Yong Wang; Payam Salehi; Barbara Barbaro; Antonio Gangemi; Joseph Kuechle; Travis Romagnoli; Michael A Hansen; Lisette A Rodriguez; Enrico Benedetti; David Hunkeler; Gudmund Skjåk-Braek; José Oberholzer Journal: Artif Cells Blood Substit Immobil Biotechnol Date: 2008
Authors: Daniel H Paushter; Meirigeng Qi; Kirstie K Danielson; Tricia A Harvat; Katie Kinzer; Barbara Barbaro; Sonny Patel; Sarah Z Hassan; Jose Oberholzer; Yong Wang Journal: Cell Transplant Date: 2012-10-02 Impact factor: 4.064
Authors: Yasuhiro Iwanaga; David Er Sutherland; James V Harmon; Klearchos K Papas Journal: Curr Opin Organ Transplant Date: 2008-08 Impact factor: 2.640
Authors: Yong Wang; Joshua E Mendoza-Elias; Meirigeng Qi; Tricia A Harvat; Sang Joon Ahn; Dongyoung Lee; Diana Gutierrez; Hyojin Jeon; Daniel Paushter; José Oberholzer Journal: Biochem Res Int Date: 2012-05-07
Authors: Alexander Kaltenborn; Jill Gwiasda; Volker Amelung; Christian Krauth; Frank Lehner; Felix Braun; Jürgen Klempnauer; Benedikt Reichert; Harald Schrem Journal: BMC Gastroenterol Date: 2014-09-28 Impact factor: 3.067