Literature DB >> 1511405

Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis.

M Tsujii1, S Kawano, S Tsuji, K Nagano, T Ito, N Hayashi, H Fusamoto, T Kamada, K Tamura.   

Abstract

Helicobacter pylori (HP) has been shown to possibly be a pathogen of gastric carcinoma. HP has urease activity and produces ammonia in the stomach. In this study, the role of ammonia on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in rats. After 24 weeks pretreatment with MNNG (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. The ammonia-treated rats showed a significantly higher incidence of gastric cancer (percent of animals with tumors and number of tumors per rat). Ammonia would thus appear to have an important role in HP-related human gastric carcinogenesis.

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Year:  1992        PMID： 1511405     DOI： 10.1016/0304-3835(92)90207-c

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  12 in total

1.  Molecular mechanisms of H. pylori associated gastric carcinogenesis.

Authors:  Zun-Wu Zhang; Michael JG Farthing
Journal:  World J Gastroenterol       Date:  1999-10       Impact factor: 5.742

2.  Enhancement by monochloramine of the development of gastric cancers in rats: a possible mechanism of Helicobacter pylori-associated gastric carcinogenesis.

Authors:  H Iishi; M Tatsuta; M Baba; T Mikuni; R Yamamoto; K Iseki; H Yano; H Uehara; A Nakaizumi
Journal:  J Gastroenterol       Date:  1997-08       Impact factor: 7.527

3.  Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis.

Authors:  G Nardone; S Staibano; A Rocco; E Mezza; F P D'armiento; L Insabato; A Coppola; G Salvatore; A Lucariello; N Figura; G De Rosa; G Budillon
Journal:  Gut       Date:  1999-06       Impact factor: 23.059

4.  Helicobacter pylori infection in patients with early gastric cancer by the endoscopic phenol red test.

Authors:  K Iseki; M Tatsuta; H Iishi; M Baba; S Ishiguro
Journal:  Gut       Date:  1998-01       Impact factor: 23.059

5.  Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma.

Authors:  C N Chen; C T Sung; M T Lin; P H Lee; K J Chang
Journal:  Ann Surg       Date:  2001-02       Impact factor: 12.969

Review 6.  Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms.

Authors:  Shingo Tsuji; Masahiko Tsujii; Hiroaki Murata; Tsutomu Nishida; Masato Komori; Masakazu Yasumaru; Shuji Ishii; Yoshiaki Sasayama; Sunao Kawano; Norio Hayashi
Journal:  World J Gastroenterol       Date:  2006-03-21       Impact factor: 5.742

7.  Features of gastritis predisposing to gastric adenoma and early gastric cancer.

Authors:  A Meining; B Riedl; M Stolte
Journal:  J Clin Pathol       Date:  2002-10       Impact factor: 3.411

Review 8.  Bacterial infection as a cause of cancer.

Authors:  J Parsonnet
Journal:  Environ Health Perspect       Date:  1995-11       Impact factor: 9.031

9.  The Helicobacter pylori fatty acid cis-9,10-methyleneoctadecanoic acid stimulates protein kinase C and increases DNA synthesis of gastric HM02 cells.

Authors:  W Beil; B Obst; S Wagner; K F Sewing
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640

10.  Effect of ingestion of soy yogurt on intestinal parameters of rats fed on a beef-based animal diet.

Authors:  Raquel Bedani; Nadiége Dourado Pauly-Silveira; Veridiana Soares Pereira Cano; Sandro Roberto Valentini; Graciela Font de Rossi; Elizeu Antonio Valdez
Journal:  Braz J Microbiol       Date:  2011-09-01       Impact factor: 2.476
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