Literature DB >> 15111240

Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats.

G Díaz-Véliz1, S Mora, H Lungenstrass, J Segura-Aguilar.   

Abstract

The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when they were stimulated with apomorphine (0.5 mg/kg, s.c.), similar to rats injected unilaterally with 6-hydroxydopamine (6-OHDA). These rats also exhibited impairment of motor and cognitive behaviours. The results support the hypothesis that DT-diaphorase plays a protective role in the nigrostriatal dopaminergic systems.

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Year:  2004        PMID： 15111240     DOI： 10.1007/BF03033183

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.978


  11 in total

1.  Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.

Authors:  P Martinez-Alvarado; A Dagnino-Subiabre; I Paris; D Metodiewa; C J Welch; C Olea-Azar; P Caviedes; R Caviedes; J Segura-Aguilar
Journal:  Biochem Biophys Res Commun       Date:  2001-05-25       Impact factor: 3.575

Review 2.  Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons.

Authors:  M Naoi; W Maruyama; Y Akao; J Zhang; H Parvez
Journal:  Toxicology       Date:  2000-11-16       Impact factor: 4.221

3.  A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain.

Authors:  W Maruyama; G Sobue; K Matsubara; Y Hashizume; P Dostert; M Naoi
Journal:  Neurosci Lett       Date:  1997-02-14       Impact factor: 3.046

4.  Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey.

Authors:  J S Schneider; A Pope-Coleman
Journal:  Neurodegeneration       Date:  1995-09

Review 5.  Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease.

Authors:  J Kulisevsky
Journal:  Drugs Aging       Date:  2000-05       Impact factor: 3.923

Review 6.  Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease.

Authors:  Makoto Naoi; Wakako Maruyama; Yukihiro Akao; Hong Yi
Journal:  Neurotoxicol Teratol       Date:  2002 Sep-Oct       Impact factor: 3.763

7.  Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D2 receptor sites.

Authors:  M Herrera-Marschitz; U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1984-02-17       Impact factor: 4.432

8.  Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies.

Authors:  M Naoi; W Maruyama; P Dostert; Y Hashizume; D Nakahara; T Takahashi; M Ota
Journal:  Brain Res       Date:  1996-02-19       Impact factor: 3.252

9.  Inhibition of DT-diaphorase is a requirement for Mn(III) to produce a 6-OH-dopamine like rotational behaviour.

Authors:  J Segura-Aguilar; G Diaz-Veliz; S Mora; M Herrera-Marschitz
Journal:  Neurotox Res       Date:  2002-03       Impact factor: 3.911

10.  Formation of novel toxic compounds from oxidative interaction between salsolinol and cysteine.

Authors:  Fa Zhang
Journal:  J Pharm Biomed Anal       Date:  2002-09-05       Impact factor: 3.935
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  7 in total

Review 1.  Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease.

Authors:  Irmgard Paris; Sergio Cardenas; Jorge Lozano; Carolina Perez-Pastene; Rebecca Graumann; Alejandra Riveros; Pablo Caviedes; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2007-09       Impact factor: 3.911

Review 2.  Neurotoxins and neurotoxicity mechanisms. An overview.

Authors:  Juan Segura-Aguilar; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2006-12       Impact factor: 3.911

Review 3.  Neurotoxins and neurotoxic species implicated in neurodegeneration.

Authors:  Juan Segura Aguilar; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

4.  Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death.

Authors:  Irmgard Paris; Carolina Perez-Pastene; Eduardo Couve; Pablo Caviedes; Susan Ledoux; Juan Segura-Aguilar
Journal:  J Biol Chem       Date:  2009-03-05       Impact factor: 5.157

5.  Molecular and neurochemical mechanisms in PD pathogenesis.

Authors:  Irmgard Paris; Jorge Lozano; Carolina Perez-Pastene; Patricia Muñoz; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2009-05-20       Impact factor: 3.911

6.  Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

Authors:  Ismael Palacios-García; Ariel Lara-Vásquez; Juan F Montiel; Gabriela F Díaz-Véliz; Hugo Sepúlveda; Elías Utreras; Martín Montecino; Christian González-Billault; Francisco Aboitiz
Journal:  PLoS One       Date:  2015-02-13       Impact factor: 3.240

Review 7.  Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.

Authors:  Magdalena Kurnik-Łucka; Pertti Panula; Andrzej Bugajski; Krzysztof Gil
Journal:  Neurotox Res       Date:  2017-10-23       Impact factor: 3.911
  7 in total

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