| Literature DB >> 15110837 |
Małgorzata Dukat1, Carol Smith, Katharine Herrick-Davis, Milt Teitler, Richard A Glennon.
Abstract
Structure-affinity requirements for the binding of serotonin (5-HT) analogs at human 5-HT1E receptors were investigated by examining the affinities of >40 tryptamine-related compounds. No tryptamine analog was found to bind with substantially higher affinity than 5-HT. The results indicate that hydrogen bonding plays a key role in the 5-HT1E/receptor interaction. This finding was supported using quantitative structure-activity analysis (QSAR) techniques such as comparative molecular field analysis (CoMFA) and the program QsarIS.Entities:
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Year: 2004 PMID： 15110837 DOI： 10.1016/j.bmc.2004.03.026
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641