| Literature DB >> 15109967 |
Vladimir Trajkovic1, Krishnamurthy Natarajan, Pawan Sharma.
Abstract
The recently discovered RD1 locus encodes proteins that are actively secreted by pathogenic mycobacteria, including Mycobacterium tuberculosis. Since they are missing in non-tuberculous mycobacteria, these proteins are promising not only as candidates for vaccination and diagnostic tests, but also in understanding mycobacterial evasion of protective immunity in susceptible individuals. Here we analyze the possible role of M. tuberculosis secretory proteins in immunity against tuberculosis, with emphasis on their immunomodulatory action and the potential involvement in mycobacterial subversion of the host immune defense.Entities:
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Year: 2004 PMID： 15109967 DOI： 10.1016/j.micinf.2003.12.015
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700