| Literature DB >> 15109671 |
Vincent P Rocco1, Patrick G Spinazze, Todd J Kohn, Nicholas A Honigschmidt, David L Nelson, D Bradley Wainscott, Laura J Ahmad, Janice Shaw, Penny G Threlkeld, David T Wong, Kumiko Takeuchi.
Abstract
A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring.Entities:
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Year: 2004 PMID： 15109671 DOI： 10.1016/j.bmcl.2004.02.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823