| Literature DB >> 15109669 |
Hing L Sham1, David A Betebenner, William Rosenbrook, Thomas Herrin, Ayda Saldivar, Sudthida Vasavanonda, Jacob J Plattner, Daniel W Norbeck.
Abstract
The HIV protease inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure-activity relationships explored.Entities:
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Year: 2004 PMID： 15109669 DOI： 10.1016/j.bmcl.2004.02.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823