| Literature DB >> 15109649 |
Helen Y Chen1, Seongkon Kim, Jane Y Wu, Elizabeth T Birzin, Wanda Chan, Yi Tien Yang, Johanna Dahllund, Frank DiNinno, Susan P Rohrer, James M Schaeffer, Milton L Hammond.
Abstract
A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathiin analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ER alpha over ER beta, but were less potent than the original lead compound 1a in the inhibition of estradiol-driven uterine proliferation.Entities:
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Year: 2004 PMID： 15109649 DOI： 10.1016/j.bmcl.2004.02.084
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823