Literature DB >> 15109640

Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.

Hyun-Suk Lim1, Jeong-Ju Park, Kwangseok Ko, Mee-Hyun Lee, Sung-Kee Chung.   

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.

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Year:  2004        PMID： 15109640     DOI： 10.1016/j.bmcl.2004.03.001

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.

Authors:  Dong-Soon Im
Journal:  Acta Pharmacol Sin       Date:  2010-08-23       Impact factor: 6.150

2.  Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.

Authors:  Frank W Foss; Ashley H Snyder; Michael D Davis; Michael Rouse; Mark D Okusa; Kevin R Lynch; Timothy L Macdonald
Journal:  Bioorg Med Chem       Date:  2006-11-01       Impact factor: 3.641

3.  Molecular recognition in the sphingosine 1-phosphate receptor family.

Authors:  Truc-Chi T Pham; James I Fells; Daniel A Osborne; E Jeffrey North; Mor M Naor; Abby L Parrill
Journal:  J Mol Graph Model       Date:  2007-11-17       Impact factor: 2.518

4.  Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.

Authors:  Yuichi Inagaki; Trucchi T Pham; Yuko Fujiwara; Takayuki Kohno; Daniel A Osborne; Yasuyuki Igarashi; Gabor Tigyi; Abby L Parrill
Journal:  Biochem J       Date:  2005-07-01       Impact factor: 3.857

Review 5.  Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.

Authors:  Abby L Parrill; Gabor Tigyi
Journal:  Biochim Biophys Acta       Date:  2012-09-12

6.  Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.

Authors:  Mor M Naor; Michelle D Walker; James R Van Brocklyn; Gabor Tigyi; Abby L Parrill
Journal:  J Mol Graph Model       Date:  2007-03-14       Impact factor: 2.518

Review 7.  Lysophospholipid interactions with protein targets.

Authors:  Abby L Parrill
Journal:  Biochim Biophys Acta       Date:  2008-05-02

Review 8.  Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.

Authors:  M T M van Jaarsveld; J M Houthuijzen; E E Voest
Journal:  Oncogene       Date:  2015-12-07       Impact factor: 9.867
  8 in total

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