| Literature DB >> 15109638 |
Jozsef Aszodi1, David A Rowlands, Pascale Mauvais, Pascal Collette, Alain Bonnefoy, Maxime Lampilas.
Abstract
Anti-Bredt bridged bicyclo[3.2.1] gamma-lactams were designed as inhibitors of penicillin binding proteins (PBPs). The compounds were prepared by a carbenoid insertion into a lactam N-H bond. Their weak antibacterial activity could either be explained by a poor chemical stability or by unfavorable steric interactions of the methylene bridge of the gamma-lactam with the targeted enzymes.Entities:
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Year: 2004 PMID： 15109638 DOI： 10.1016/j.bmcl.2004.03.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823