Literature DB >> 15109556

Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar.

M L Willcox1, E Rakotondrazafy, R Andriamanalimanana, D Andrianasolo, P Rasoanaivo.   

Abstract

The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.

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Year:  2004        PMID: 15109556     DOI: 10.1016/j.trstmh.2003.10.002

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN: 0035-9203            Impact factor:   2.184


  3 in total

1.  Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.

Authors:  Valérie Andriantsoanirina; Arsène Ratsimbasoa; Christiane Bouchier; Martial Jahevitra; Stéphane Rabearimanana; Rogelin Radrianjafy; Voahangy Andrianaranjaka; Tantely Randriantsoa; Marie Ange Rason; Magali Tichit; Léon Paul Rabarijaona; Odile Mercereau-Puijalon; Rémy Durand; Didier Ménard
Journal:  Antimicrob Agents Chemother       Date:  2009-08-24       Impact factor: 5.191

2.  Drug-resistant malaria parasites introduced into Madagascar from Comoros Islands.

Authors:  Didier Ménard; Armand Eugène Randrianarivo-Solofoniaina; Bedja Said Ahmed; Martial Jahevitra; Valérie Andriantsoanirina; Justin Ranjalahy Rasolofomanana; Léon Paul Rabarijaona
Journal:  Emerg Infect Dis       Date:  2007-11       Impact factor: 6.883

3.  Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.

Authors:  Didier Ménard; Nohary Nina Harimanana Andrianina; Zakaherizo Ramiandrasoa; Arthur Randriamanantena; Noéline Rasoarilalao; Martial Jahevitra; Arsène Ratsimbasoa; Luciano Tuseo; Andrianirina Raveloson
Journal:  Malar J       Date:  2007-05-22       Impact factor: 2.979

  3 in total

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