Literature DB >> 15108802

Aurora kinases link chromosome segregation and cell division to cancer susceptibility.

Patrick Meraldi1, Reiko Honda, Erich A Nigg.   

Abstract

Aurora kinases play critical roles in chromosome segregation and cell division. They are implicated in the centrosome cycle, spindle assembly, chromosome condensation, microtubule-kinetochore attachment, the spindle checkpoint and cytokinesis. Aurora kinases are regulated through phosphorylation, the binding of specific partners and ubiquitin-dependent proteolysis. Several Aurora substrates have been identified and their roles are being elucidated. The deregulation of Aurora kinases impairs spindle assembly, checkpoint function and cell division, causing missegregation of individual chromosomes or polyploidization accompanied by centrosome amplification. Aurora kinases are frequently overexpressed in cancers and the identification of Aurora A as a cancer-susceptibility gene provides a strong link between mitotic errors and carcinogenesis.

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Year:  2004        PMID： 15108802     DOI： 10.1016/j.gde.2003.11.006

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  118 in total

Review 1.  Chromosomal passengers: the four-dimensional regulation of mitotic events.

Authors:  Paola Vagnarelli; William C Earnshaw
Journal:  Chromosoma       Date:  2004-09-04       Impact factor: 4.316

2.  Aurora B interaction of centrosomal Nlp regulates cytokinesis.

Authors:  Jie Yan; Shunqian Jin; Jia Li; Qimin Zhan
Journal:  J Biol Chem       Date:  2010-09-23       Impact factor: 5.157

Review 3.  Illicit survival of cancer cells during polyploidization and depolyploidization.

Authors:  I Vitale; L Galluzzi; L Senovilla; A Criollo; M Jemaà; M Castedo; G Kroemer
Journal:  Cell Death Differ       Date:  2010-11-12       Impact factor: 15.828

Review 4.  Heterochromatin instability in cancer: from the Barr body to satellites and the nuclear periphery.

Authors:  Dawn M Carone; Jeanne B Lawrence
Journal:  Semin Cancer Biol       Date:  2012-06-18       Impact factor: 15.707

5.  Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells.

Authors:  Dimpy Koul; Jun Fu; Ruijun Shen; Tiffany A LaFortune; Shuzhen Wang; Ningyi Tiao; Yong-Wan Kim; Juinn-Lin Liu; Deepti Ramnarian; Ying Yuan; Carlos Garcia-Echevrria; Sauveur-Michel Maira; W K Alfred Yung
Journal:  Clin Cancer Res       Date:  2011-11-07       Impact factor: 12.531

6.  Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.

Authors:  Bedrick B Gadea; Joan V Ruderman
Journal:  Mol Biol Cell       Date:  2004-12-22       Impact factor: 4.138

Review 7.  Kiss and break up--a safe passage to anaphase in mitosis and meiosis.

Authors:  Jeffrey M Craig; K H Andy Choo
Journal:  Chromosoma       Date:  2005-10-15       Impact factor: 4.316

8.  Aurora A, mitotic entry, and spindle bipolarity.

Authors:  Quentin Liu; Joan V Ruderman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-31       Impact factor: 11.205

9.  Aurora-A kinase is essential for bipolar spindle formation and early development.

Authors:  Dale O Cowley; Jaime A Rivera-Pérez; Mark Schliekelman; Yizhou Joseph He; Trudy G Oliver; Lucy Lu; Ryan O'Quinn; E D Salmon; Terry Magnuson; Terry Van Dyke
Journal:  Mol Cell Biol       Date:  2008-12-15       Impact factor: 4.272

10.  Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.

Authors:  Su-Yeon Lee; Eun-Young Kim; Kyeoung-Hwa Kim; Kyung-Ah Lee
Journal:  Cell Cycle       Date:  2016-10-18       Impact factor: 4.534
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