Literature DB >> 1510813

VDJ recombination.

F W Alt, E M Oltz, F Young, J Gorman, G Taccioli, J Chen.   

Abstract

The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

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Year:  1992        PMID： 1510813     DOI： 10.1016/0167-5699(92)90043-7

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  95 in total

1.  Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor.

Authors:  P Bousso; V Wahn; I Douagi; G Horneff; C Pannetier; F Le Deist; F Zepp; T Niehues; P Kourilsky; A Fischer; G de Saint Basile
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

Review 2.  Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.

Authors:  M Diaz; M F Flajnik; N Klinman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

3.  The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.

Authors:  F Davodeau; M Difilippantonio; E Roldan; M Malissen; J L Casanova; C Couedel; J F Morcet; M Merkenschlager; A Nussenzweig; M Bonneville; B Malissen
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

4.  Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion.

Authors:  Yasushi Miura; Charles C Chu; David M Dines; Stanley E Asnis; Richard A Furie; Nicholas Chiorazzi
Journal:  Mol Med       Date:  2003 May-Aug       Impact factor: 6.354

5.  Analysis of differential immune responses induced by innate and adaptive immunity following transplantation.

Authors:  Hongzhen He; James R Stone; David L Perkins
Journal:  Immunology       Date:  2003-06       Impact factor: 7.397

6.  Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

Authors:  Kazuhiko Kuwahara; Satoru Fujimura; Yoshimasa Takahashi; Naomi Nakagata; Toshitada Takemori; Shinichi Aizawa; Nobuo Sakaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-08       Impact factor: 11.205

7.  Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Authors:  Jeremy A Goettel; Subhabrata Biswas; Willem S Lexmond; Ada Yeste; Laura Passerini; Bonny Patel; Siyoung Yang; Jiusong Sun; Jodie Ouahed; Dror S Shouval; Katelyn J McCann; Bruce H Horwitz; Diane Mathis; Edgar L Milford; Luigi D Notarangelo; Maria-Grazia Roncarolo; Edda Fiebiger; Wayne A Marasco; Rosa Bacchetta; Francisco J Quintana; Sung-Yun Pai; Christoph Klein; Aleixo M Muise; Scott B Snapper
Journal:  Blood       Date:  2015-04-01       Impact factor: 22.113

8.  Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.

Authors:  T Dörner; S J Foster; N L Farner; P E Lipsky
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

Review 9.  Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic applications and their limits.

Authors:  H Griesser
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

10.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205
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