| Literature DB >> 15106859 |
Elisabetta Cagetti1, Kate J Baicy, Richard W Olsen.
Abstract
Topiramate, a novel anticonvulsant drug, has CNS depressant activity including enhancement of GABAergic inhibitory synaptic transmission. Drugs of this pharmacological spectrum might have utility in assuaging drug addiction. This study analyzes the ability of TPM to reduce withdrawal signs in the kindling model of ethanol dependence: chronic intermittent ethanol (CIE) rats. After CIE, persistent withdrawal signs are shown by an increased seizure susceptibility to the convulsant drug pentylenetetrazol and increased anxiety measured on the elevated plus-maze. Topiramate increased significantly the PTZ seizure threshold in CIE but not in control rats. On the elevated plus-maze, Topiramate was markedly more effective in CIE rats than in controls. Topiramate may have a therapeutic efficacy in treating alcohol withdrawal symptoms.Entities:
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Year: 2004 PMID： 15106859 DOI： 10.1097/00001756-200401190-00040
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837