Literature DB >> 15106847

Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin.

Georg Reiser1, Hans-Gert Bernstein.   

Abstract

The protein p42IP4 (centaurin-alpha1) is a brain-specific InsP4/PtdIns3 (PIP)-binding protein, whish is localized in neurons of the human brain. In Alzheimer's disease (AD) the intraneuronal expression of the protein was shown to be elevated. In addition, p42IP4 immunostaining decorated neuritic plaques. Attempting to explain the putative role of the protein in AD, we have concentrated on its well-known interactions with casein kinase I, which is known to be prominently involved in AD pathophysiology. Meanwhile, specific interaction of p42IP4 with nucleolin, another player in AD pathology, has been revealed. Based on these data, we propose alternative concepts of how p42IP4 might act in AD pathomechanisms.

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Year:  2004        PMID： 15106847     DOI： 10.1097/00001756-200401190-00028

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

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Journal:  Physiol Genomics       Date:  2007-06-19       Impact factor: 3.107

2.  Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.

Authors:  Yufeng Tong; Wolfram Tempel; Hui Wang; Kaori Yamada; Limin Shen; Guillermo A Senisterra; Farrell MacKenzie; Athar H Chishti; Hee-Won Park
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-05       Impact factor: 11.205

3.  Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.

Authors:  Hans-Gert Bernstein; Rolf Stricker; Uwe Lendeckel; Iris Bertram; Henrik Dobrowolny; Johann Steiner; Bernhard Bogerts; Georg Reiser
Journal:  Age (Dordr)       Date:  2008-08-30

4.  The role of cerebellar genes in pathology of autism and schizophrenia.

Authors:  S Hossein Fatemi; Teri J Reutiman; Timothy D Folsom; Robert W Sidwell
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

5.  Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms.

Authors:  Sandra L Rodriguez-Zas; Cong Wu; Bruce R Southey; Jason C O'Connor; Scott E Nixon; Robmay Garcia; Cynthia Zavala; Marcus Lawson; Robert H McCusker; Elena V Romanova; Jonathan V Sweedler; Keith W Kelley; Robert Dantzer
Journal:  Psychoneuroendocrinology       Date:  2018-06-30       Impact factor: 4.905

6.  Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.

Authors:  Erzsebet M Szatmari; Ana F Oliveira; Elizabeth J Sumner; Ryohei Yasuda
Journal:  J Neurosci       Date:  2013-03-20       Impact factor: 6.167

7.  The PIKE homolog Centaurin gamma regulates developmental timing in Drosophila.

Authors:  Anna Lisa Gündner; Ines Hahn; Oliver Sendscheid; Hermann Aberle; Michael Hoch
Journal:  PLoS One       Date:  2014-05-20       Impact factor: 3.240
  7 in total

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