| Literature DB >> 15106598 |
Ikuo Nishimoto1, Masaaki Matsuoka, Takako niikura.
Abstract
Humanin (HN), a recently identified neuroprotective factor against Alzheimer's disease-related insults, has been reported to function as an anti cell-death factor through multiple mechanisms. One mechanism, revealed in a glioblastoma cell line, involves the apoptosis-inducing protein Bax. This, in addition to the fact that HN is produced in certain normal tissues, such as testis, implies a potential role of HN in oncogenesis. A second mechanism, in neuronal cells, is via a putative cell-surface receptor. It is through this mechanism that HN exhibits its neuroprotective activity.Entities:
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Year: 2004 PMID： 15106598 DOI： 10.1016/j.molmed.2004.01.001
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951