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Literature DB >> 1510458

Evaluation of the usefulness of a novel injectable cephalosporin, E1040, and ceftazidime for management of complicated urinary tract infections caused by Pseudomonas aeruginosa and Proteus mirabilis by using the rat urolithiasis model.

M Satoh¹, K Munakata, H Takeuchi, O Yoshida.

Abstract

A novel injectable cephalosporin, E1040, significantly eradicated Pseudomonas aeruginosa from the urine, in contrast to ceftazidime, in rats with complicated P. aeruginosa urinary tract infections associated with urinary stones, suggesting that E1040 is a prospective therapeutic agent in the management of refractory Pseudomonas urinary tract infections.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1510458 PMCID： PMC191627 DOI： 10.1128/AAC.36.7.1580

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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References

12 in total

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Evaluation of the usefulness of a novel injectable cephalosporin, E1040, and ceftazidime for management of complicated urinary tract infections caused by Pseudomonas aeruginosa and Proteus mirabilis by using the rat urolithiasis model.

1. A microdiffusion method for the determination of nitrogen liberated as ammonia.

2. Bacteriology of infected stones.

3. Surgical, bacteriological, and biochemical management of "infection stones".

4. Scanning electron microscopy detects bacteria within infection stones.

5. In vitro activity of E-1040, a 3-substituted cephalosporin, against pathogens from cystic fibrosis sputum.

6. [Urinary tract infection associated with urinary calculi. 2. Effects of antibiotics on bacteria within infected stones].

7. A newly designed model for infection-induced bladder stone formation in the rat.

8. In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.

9. In vitro activity of E-1040, a novel cephalosporin with potent activity against Pseudomonas aeruginosa.

10. Bacteriological study of renal calculi.