Literature DB >> 15104480

New chromanone acids with antibacterial activity from Calophyllum brasiliense.

Filippo Cottiglia1, Boopathy Dhanapal, Otto Sticher, Jörg Heilmann.   

Abstract

Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxic against KB, Jurkat T, and myosarcoma cancer cells up to 20 microg/mL.

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Year:  2004        PMID: 15104480     DOI: 10.1021/np030438n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  4 in total

1.  Anti-Mycobacterium tuberculosis activity and cytotoxicity of Calophyllum brasiliense Cambess (Clusiaceae).

Authors:  Claudia Terencio Agostinho Pires; Mislaine Adriana Brenzan; Regiane Bertin de Lima Scodro; Diógenes Aparício Garcia Cortez; Luciana Dias Ghiraldi Lopes; Vera Lucia Dias Siqueira; Rosilene Fressatti Cardoso
Journal:  Mem Inst Oswaldo Cruz       Date:  2014-03-04       Impact factor: 2.743

2.  Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.

Authors:  Larissa M S Lemos; Fabio Miyajima; Geovane R C Castilho; Domingos Tabajara O Martins; D Mark Pritchard; Michael D Burkitt
Journal:  Front Pharmacol       Date:  2017-02-27       Impact factor: 5.810

Review 3.  Chemical constituents of the plants of the genus Calophyllum.

Authors:  Xiao-Hui Su; Man-Li Zhang; Li-Geng Li; Chang-Hong Huo; Yu-Cheng Gu; Qing-Wen Shi
Journal:  Chem Biodivers       Date:  2008-12       Impact factor: 2.408

4.  Rigid 3D-spiro chromanone as a crux for efficient antimicrobial agents: synthesis, biological and computational evaluation.

Authors:  F H Elghareeb; E M Kandil; M Abou-Elzahab; M Abdelmoteleb; M A Abozeid
Journal:  RSC Adv       Date:  2021-06-16       Impact factor: 4.036

  4 in total

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