Literature DB >> 15103676

Antiprotozoal effect of crude extracts and flavonoids isolated from Chromolaena hirsuta (asteraceae).

S H Taleb-Contini1, M J Salvador, J M F Balanco, S Albuquerque, D C R de Oliveira.   

Abstract

Phytochemical study of Chromolaena hirsuta (Hook. & Arn.) R. King & H. Robinson crude extract (collected in Furnas, MG-Brasil) produced fifteen flavonoids, two triterpenes and five steroids. IR, UV,(1)H and (13)C NMR spectroscopy and GC analysis were used for the identification of these compounds. The dichloromethanic and ethanolic crude extracts (flowers and leaves) and six flavonoids isolated from this specie have been assayed for antiprotozoal activity against tripomastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania amazonensis. The crude extracts significantly reduced the viability of T. cruzi and Leishmania amazonensis, and the six flavonoids showed considerable antiproliferative effect of development of two parasites evaluated. This is the fi rst report of antiprotozoal activity of extracts of C. hirsuta. Copyright 2004 John Wiley & Sons, Ltd.

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Year:  2004        PMID： 15103676     DOI： 10.1002/ptr.1431

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  7 in total

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3.  Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves.

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4.  Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr.

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5.  Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target.

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Review 7.  The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis.

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  7 in total

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