Literature DB >> 15103428

Imaging of malignant tumours of the long bones in children: monitoring response to neoadjuvant chemotherapy and preoperative assessment.

Hervé Brisse1, Liliane Ollivier, Véronique Edeline, Hélène Pacquement, Jean Michon, Christophe Glorion, Sylvia Neuenschwander.   

Abstract

This review focuses on imaging of osteosarcoma and Ewing's sarcoma of the long bones in children during preoperative neoadjuvant chemotherapy. Morphological criteria on plain films and conventional static MRI are insufficiently correlated with histological response. We review the contribution of dynamic MRI, diffusion-weighted MR and nuclear medicine (18FDG-PET) to monitor tumoural necrosis. MRI is currently the best method to evaluate local extension prior to tumour resection, especially to assess the feasibility of conservative surgery. Quantitative models in dynamic MRI and 18FDG-PET are currently being developed in order to find new early prognostic criteria, but for the time being, treatment protocols are still based on the gold standard of histological response.

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Mesh：

Year:  2004        PMID： 15103428     DOI： 10.1007/s00247-004-1192-x

Source DB:  PubMed          Journal:  Pediatr Radiol        ISSN： 0301-0449


  83 in total

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5.  MR imaging of bone marrow in children with osteosarcoma: effect of granulocyte colony-stimulating factor.

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6.  Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.

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10.  Musculoskeletal neoplasms: preoperative evaluation with MR angiography.

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  27 in total

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4.  Response to chemotherapy estimates by FDG PET is an important prognostic factor in patients with Ewing sarcoma.

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5.  Value of diffusion-weighted images in differentiating mid-course responders to chemotherapy for osteosarcoma compared to the histological response: preliminary results.

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6.  Role of MRI in osteosarcoma for evaluation and prediction of chemotherapy response: correlation with histological necrosis.

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