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Literature DB >> 15102823

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins.

Gerd Haug¹, Klaus Aktories, Holger Barth.

Abstract

The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.

Entities: Chemical Species

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Year: 2004 PMID： 15102823 PMCID： PMC387881 DOI： 10.1128/IAI.72.5.3066-3068.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells.

Authors: Dagmar Blöcker; Kathrin Pohlmann; Gerd Haug; Christoph Bachmeyer; Roland Benz; Klaus Aktories; Holger Barth
Journal: J Biol Chem Date: 2003-07-17 Impact factor: 5.157

2. Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification.

Authors: H Barth; D Blocker; J Behlke; W Bergsma-Schutter; A Brisson; R Benz; K Aktories
Journal: J Biol Chem Date: 2000-06-23 Impact factor: 5.157

3. Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.

Authors: I Gülke; G Pfeifer; J Liese; M Fritz; F Hofmann; K Aktories; H Barth
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

4. Purification and characterization of two components of botulinum C2 toxin.

Authors: I Ohishi; M Iwasaki; G Sakaguchi
Journal: Infect Immun Date: 1980-12 Impact factor: 3.441

5. Botulinum C2 toxin ADP-ribosylates actin.

Authors: K Aktories; M Bärmann; I Ohishi; S Tsuyama; K H Jakobs; E Habermann
Journal: Nature Date: 1986 Jul 24-30 Impact factor: 49.962

6. Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli.

Authors: S Perelle; M Gibert; P Boquet; M R Popoff
Journal: Infect Immun Date: 1993-12 Impact factor: 3.441

Review 7. The uptake machinery of clostridial actin ADP-ribosylating toxins--a cell delivery system for fusion proteins and polypeptide drugs.

Authors: Holger Barth; Dagmar Blöcker; Klaus Aktories
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2002-09-24 Impact factor: 3.000

8. Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity.

Authors: B G Stiles; T D Wilkins
Journal: Infect Immun Date: 1986-12 Impact factor: 3.441

9. The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol.

Authors: Gerd Haug; Jost Leemhuis; Dirk Tiemann; Dieter K Meyer; Klaus Aktories; Holger Barth
Journal: J Biol Chem Date: 2003-06-12 Impact factor: 5.157

10. The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.

Authors: Ryan Ratts; Huiyan Zeng; Eric A Berg; Clare Blue; Mark E McComb; Cathy E Costello; Johanna C vanderSpek; John R Murphy
Journal: J Cell Biol Date: 2003-03-31 Impact factor: 10.539

29 in total

Review 1. Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors.

Authors: Holger Barth
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2010-12-01 Impact factor: 3.000

Review 2. Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection.

Authors: Brian Henderson; Elaine Allan; Anthony R M Coates
Journal: Infect Immun Date: 2006-07 Impact factor: 3.441

3. HSC70 and HSP90 chaperones perform complementary roles in translocation of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.

Authors: Helen Burress; Alisha Kellner; Jessica Guyette; Suren A Tatulian; Ken Teter
Journal: J Biol Chem Date: 2019-06-20 Impact factor: 5.157

4. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B.

Authors: Marcus Steinemann; Andreas Schlosser; Thomas Jank; Klaus Aktories
Journal: Proc Natl Acad Sci U S A Date: 2018-09-04 Impact factor: 11.205

5. Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

Authors: Eva Kaiser; Claudia Kroll; Katharina Ernst; Carsten Schwan; Michel Popoff; Gunter Fischer; Johannes Buchner; Klaus Aktories; Holger Barth
Journal: Infect Immun Date: 2011-07-18 Impact factor: 3.441

Review 6. The role of toxins in Clostridium difficile infection.

Authors: Ramyavardhanee Chandrasekaran; D Borden Lacy
Journal: FEMS Microbiol Rev Date: 2017-11-01 Impact factor: 16.408

7. Co- and post-translocation roles for HSP90 in cholera Intoxication.

Authors: Helen Burress; Michael Taylor; Tuhina Banerjee; Suren A Tatulian; Ken Teter
Journal: J Biol Chem Date: 2014-10-15 Impact factor: 5.157

Review 8. Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors: Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal: Microbiol Mol Biol Rev Date: 2004-09 Impact factor: 11.056

9. Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78.

Authors: Sweta Das; Amruta Mohapatra; P K Sahoo
Journal: Cell Stress Chaperones Date: 2014-07-19 Impact factor: 3.667

10. gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.

Authors: Xi Na; Ho Kim; Mary P Moyer; Charalabos Pothoulakis; J Thomas LaMont
Journal: Infect Immun Date: 2008-04-14 Impact factor: 3.441