Literature DB >> 15102440

Matrix remodeling during endochondral ossification.

Nathalie Ortega1, Danielle J Behonick, Zena Werb.   

Abstract

Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role of the matrix metalloproteases (MMPs) not only as simple effectors of ECM degradation but also as regulators of active signal-inducers for the initiation of endochondral ossification. The daunting task of elucidating their specific role during endochondral ossification has been facilitated by the development of mice deficient for various members of this family. Here, we discuss the ECM and its remodeling as one level of molecular regulation for the process of endochondral ossification, with special attention to the MMPs.

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Year:  2004        PMID: 15102440      PMCID: PMC2779708          DOI: 10.1016/j.tcb.2003.12.003

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN: 0962-8924            Impact factor:   20.808


  57 in total

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Review 1.  Coculture strategies in bone tissue engineering: the impact of culture conditions on pluripotent stem cell populations.

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2.  Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors.

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Journal:  Biophys J       Date:  2005-05-13       Impact factor: 4.033

Review 5.  Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs.

Authors:  Jan O Gordeladze; Farida Djouad; Jean-Marc Brondello; Daniele Noël; Isabelle Duroux-Richard; Florence Apparailly; Christian Jorgensen
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6.  Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation.

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Journal:  Dev Biol       Date:  2006-05-27       Impact factor: 3.582

7.  In vivo delivery of fluoresceinated dextrans to the murine growth plate: imaging of three vascular routes by multiphoton microscopy.

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8.  Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways.

Authors:  Xianrong Zhang; Ji Zhu; Yumei Li; Tiao Lin; Valerie A Siclari; Abhishek Chandra; Elena M Candela; Eiki Koyama; Motomi Enomoto-Iwamoto; Ling Qin
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9.  Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids.

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10.  Dyggve-Melchior-Clausen syndrome: chondrodysplasia resulting from defects in intracellular vesicle traffic.

Authors:  Anna B Osipovich; Jennifer L Jennings; Qing Lin; Andrew J Link; H Earl Ruley
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