Literature DB >> 15101763

Stereoselective total synthesis of antitumor macrolide (+)-rhizoxin D.

Yueheng Jiang1, Jian Hong, Steven D Burke.   

Abstract

[structure: see text] A convergent, stereoselective total synthesis of the macrolide antitumor agent rhizoxin D is described. (+)-DIPCl-promoted asymmetric aldol reaction, Evans-Tishchenko 1,3-diol synthesis, modified Julia coupling, and Horner-Wadsworth-Emmons reactions are featured.

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Year:  2004        PMID: 15101763     DOI: 10.1021/ol049701h

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Enantioselective Evans-Tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate.

Authors:  Tomonori Ichibakase; Masato Nakatsu; Makoto Nakajima
Journal:  Molecules       Date:  2011-06-17       Impact factor: 4.411

  1 in total

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