| Literature DB >> 15099824 |
Shinji Takechi1, Tadatoshi Yamaguchi, Hajime Nomura, Toshio Minematsu, Tatsuo Nakayama.
Abstract
Dihydropyrazine (DHP) causes DNA strand breaks in vitro. We evaluated the cytotoxic and genotoxic potential of DHP in Escherichia coli. DHP exposure dose-dependently caused inhibition of cell growth in the wild-type strain, death in recA and uvrB, and an increase in mutation frequency in uvrB. These findings indicate that DHP causes DNA strand breaks in vivo.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15099824 DOI： 10.1016/j.mrgentox.2004.02.007
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433