OBJECTIVE: To evaluate the additional value of a second basal follicle stimulating hormone (FSH) level, in a different cycle, in the prediction of poor response in in vitro fertilization (IVF) by a single basal FSH measurement. STUDY DESIGN: In 120 patients, basal FSH was determined prospectively in 2 spontaneous cycles. The additional value of a second basal FSH measurement in the prediction of poor ovarian response in IVF by a single basal FSH measurement was studied. RESULTS: Due to chance variation, the predictive accuracy of a poor response of the first and second basal FSH measurement differed (ROC(AUC) .84 and .74, respectively). In a multivariate analysis, the higher of the first and second basal FSH levels provided the best predictive accuracy (ROC(AUC) .85). In terms of clinical relevance, however, a predictive model with the highest basal FSH level provided only slightly more correct predictions of poor and normal ovarian response than did models based solely on a single basal FSH measurement. CONCLUSION: Using basal FSH, a substantial number of patients will be misdiagnosed with regard to their ovarian response potential in IVF, even if repeat measurement is performed.
OBJECTIVE: To evaluate the additional value of a second basal follicle stimulating hormone (FSH) level, in a different cycle, in the prediction of poor response in in vitro fertilization (IVF) by a single basal FSH measurement. STUDY DESIGN: In 120 patients, basal FSH was determined prospectively in 2 spontaneous cycles. The additional value of a second basal FSH measurement in the prediction of poor ovarian response in IVF by a single basal FSH measurement was studied. RESULTS: Due to chance variation, the predictive accuracy of a poor response of the first and second basal FSH measurement differed (ROC(AUC) .84 and .74, respectively). In a multivariate analysis, the higher of the first and second basal FSH levels provided the best predictive accuracy (ROC(AUC) .85). In terms of clinical relevance, however, a predictive model with the highest basal FSH level provided only slightly more correct predictions of poor and normal ovarian response than did models based solely on a single basal FSH measurement. CONCLUSION: Using basal FSH, a substantial number of patients will be misdiagnosed with regard to their ovarian response potential in IVF, even if repeat measurement is performed.
Authors: D J Hendriks; F J Broekmans; L F J M M Bancsi; C W N Looman; F H de Jong; E R te Velde Journal: J Assist Reprod Genet Date: 2005-02 Impact factor: 3.412
Authors: Min Hye Choi; Ji Hee Yoo; Hye Ok Kim; Sun Hwa Cha; Chan Woo Park; Kwang Moon Yang; In Ok Song; Mi Kyoung Koong; Inn Soo Kang Journal: Clin Exp Reprod Med Date: 2011-09-30
Authors: Julian A Gingold; Joseph A Lee; Michael C Whitehouse; Jorge Rodriguez-Purata; Benjamin Sandler; Lawrence Grunfeld; Tanmoy Mukherjee; Alan B Copperman Journal: Reprod Biol Endocrinol Date: 2015-08-15 Impact factor: 5.211