Literature DB >> 15097994

Circadian regulation of GABAA receptor function by CKI epsilon-CKI delta in the rat suprachiasmatic nuclei.

Ke Ning1, Lei Li, Mingxia Liao, Baosong Liu, John G Mielke, Yonghong Chen, Ying Duan, Youssef H El-Hayek, Qi Wan.   

Abstract

The type A GABA receptors are thought to mediate synchronization of clock cell activity within the suprachiasmatic nuclei (SCN). Here we report that casein kinases I epsilon and delta (CKI epsilon and CKI delta), the crucial clock regulators, form a complex with GABA(A) receptors and inhibit the receptors' function within the SCN according to a circadian rhythm. These results indicate that circadian variation of the kinase-receptor association may mediate regulation of GABA(A) receptor function by CKI epsilon-CKI delta in the SCN.

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Year:  2004        PMID： 15097994     DOI： 10.1038/nn1236

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  8 in total

Review 1.  Circadian organization of the mammalian retina: from gene regulation to physiology and diseases.

Authors:  Douglas G McMahon; P Michael Iuvone; Gianluca Tosini
Journal:  Prog Retin Eye Res       Date:  2013-12-12       Impact factor: 21.198

2.  Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.

Authors:  Carol C Cheung; Caimei Yang; Thorsten Berger; Kathrin Zaugg; Patrick Reilly; Andrew J Elia; Andrew Wakeham; Annick You-Ten; Ning Chang; Lijun Li; Qi Wan; Tak Wah Mak
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-11       Impact factor: 11.205

3.  Regulation of dopaminergic transmission and cocaine reward by the Clock gene.

Authors:  Colleen A McClung; Kyriaki Sidiropoulou; Martha Vitaterna; Joseph S Takahashi; Francis J White; Donald C Cooper; Eric J Nestler
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-20       Impact factor: 11.205

4.  Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.

Authors:  Alice Brockington; Ke Ning; Paul R Heath; Elizabeth Wood; Janine Kirby; Nicolò Fusi; Neil Lawrence; Stephen B Wharton; Paul G Ince; Pamela J Shaw
Journal:  Acta Neuropathol       Date:  2012-11-13       Impact factor: 17.088

5.  CKI isoforms α and ε regulate Star-PAP target messages by controlling Star-PAP poly(A) polymerase activity and phosphoinositide stimulation.

Authors:  Rakesh S Laishram; Christy A Barlow; Richard A Anderson
Journal:  Nucleic Acids Res       Date:  2011-07-04       Impact factor: 16.971

6.  Casein kinase I delta controls centrosome positioning during T cell activation.

Authors:  Deborah Zyss; Hani Ebrahimi; Fanni Gergely
Journal:  J Cell Biol       Date:  2011-11-28       Impact factor: 10.539

7.  A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain.

Authors:  Juan Chen; Yang Zhuang; Ya Zhang; Huabao Liao; Rui Liu; Jing Cheng; Zhifeng Zhang; Jiangdong Sun; Jingchen Gao; Xiyuran Wang; Shujun Chen; Liang Zhang; Fengyuan Che; Qi Wan
Journal:  Front Pharmacol       Date:  2022-08-15       Impact factor: 5.988

8.  An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA.

Authors:  Guo-Xiang Ruan; Gregg C Allen; Shin Yamazaki; Douglas G McMahon
Journal:  PLoS Biol       Date:  2008-10-14       Impact factor: 8.029
  8 in total

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