Literature DB >> 15095315

HERV-K(HML-2) GAG/ENV antibodies as indicator for therapy effect in patients with germ cell tumors.

Anna Kleiman1, Natalia Senyuta, Alexey Tryakin, Marlies Sauter, Apollon Karseladze, Sergei Tjulandin, Vladimir Gurtsevitch, Nikolaus Mueller-Lantzsch.   

Abstract

Germ cell tumors (GCT) are strictly associated with the expression of HERV-K(HML-2) proviruses, and the majority of GCT patients produce antibodies to structural proteins of these proviruses. The objective of our study was to determine the significance of the serological response to HERV-K(HML-2) Gag and Env proteins for diagnosis, management of GCT patients and estimation of the therapy success. The data document a strong association of HERV-K(HML-2) antibodies and the clinical manifestation of the disease and therapy success. HERV-K(HML-2) antibodies seem to have an important diagnostic value as well as indicator of chemotherapy success. Copyright 2004 Wiley-Liss, Inc.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15095315     DOI： 10.1002/ijc.11649

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  25 in total

1.  Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.

Authors:  Leonora Balaj; Ryan Lessard; Lixin Dai; Yoon-Jae Cho; Scott L Pomeroy; Xandra O Breakefield; Johan Skog
Journal:  Nat Commun       Date:  2011-02-01       Impact factor: 14.919

2.  Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors.

Authors:  Feng Wang-Johanning; Kiera Rycaj; Joshua B Plummer; Ming Li; Bingnan Yin; Katherine Frerich; Jeremy G Garza; Jianjun Shen; Kevin Lin; Peisha Yan; Sharon A Glynn; Tiffany H Dorsey; Kelly K Hunt; Stefan Ambs; Gary L Johanning
Journal:  J Natl Cancer Inst       Date:  2012-01-12       Impact factor: 13.506

3.  Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K(HML2): implications for present-day activity.

Authors:  Robert Belshaw; Anna L A Dawson; John Woolven-Allen; Joanna Redding; Austin Burt; Michael Tristem
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

Review 4.  Molecular functions of human endogenous retroviruses in health and disease.

Authors:  Maria Suntsova; Andrew Garazha; Alena Ivanova; Dmitry Kaminsky; Alex Zhavoronkov; Anton Buzdin
Journal:  Cell Mol Life Sci       Date:  2015-06-18       Impact factor: 9.261

5.  Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.

Authors:  Nina V Fuchs; Martin Kraft; Christiane Tondera; Kay-Martin Hanschmann; Johannes Löwer; Roswitha Löwer
Journal:  J Virol       Date:  2011-01-19       Impact factor: 5.103

6.  Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early-stage breast cancer.

Authors:  Feng Wang-Johanning; Ming Li; Francisco J Esteva; Kenneth R Hess; Bingnan Yin; Kiera Rycaj; Joshua B Plummer; Jeremy G Garza; Stefan Ambs; Gary L Johanning
Journal:  Int J Cancer       Date:  2013-09-13       Impact factor: 7.396

7.  Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity.

Authors:  Toshiaki Ishida; Yuichi Obata; Nobuya Ohara; Hirokazu Matsushita; Shuichiro Sato; Akiko Uenaka; Takashi Saika; Takako Miyamura; Kosuke Chayama; Yurika Nakamura; Hisashi Wada; Toshiharu Yamashita; Tsuneo Morishima; Lloyd J Old; Eiichi Nakayama
Journal:  Cancer Immun       Date:  2008-11-13

8.  Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec.

Authors:  Alessia Ruggieri; Esther Maldener; Marlies Sauter; Nikolaus Mueller-Lantzsch; Eckart Meese; Oliver T Fackler; Jens Mayer
Journal:  Retrovirology       Date:  2009-02-16       Impact factor: 4.602

Review 9.  Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease.

Authors:  Cécile Voisset; Robin A Weiss; David J Griffiths
Journal:  Microbiol Mol Biol Rev       Date:  2008-03       Impact factor: 13.044

10.  Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.

Authors:  George R Young; Mickaël J-Y Ploquin; Urszula Eksmond; Munisch Wadwa; Jonathan P Stoye; George Kassiotis
Journal:  PLoS Pathog       Date:  2012-05-10       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.