| Literature DB >> 15094937 |
Akira Shouzu1, Shosaku Nomura, Seitaro Omoto, Takashi Hayakawa, Mitsushige Nishikawa, Toshiji Iwasaka.
Abstract
Platelet-derived microparticles, activated platelets, and monocyte-derived microparticles were measured in 73 patients with diabetes mellitus. A comparative study of these parameters was performed before and after administration of ticlopidine. The number of platelet-derived microparticles and activated platelets was increased significantly in diabetic patients. Monocyte-derived microparticles were also increased significantly. After administration of ticlopidine, platelet-derived microparticles and activated platelets corrected positively, not only CD62P- and CD63-positive platelets, but also platelet-derived microparticles and monocyte-derived microparticles showed a significant decrease. These data suggest that in patients with diabetes, platelet-derived microparticles and activated platelets stimulate the activation of monocytes and promote the production of monocyte-derived microparticles, and that ticlopidine is useful for hypercoagulabillity in diabetic patients.Entities:
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Year: 2004 PMID： 15094937 DOI： 10.1177/107602960401000207
Source DB: PubMed Journal: Clin Appl Thromb Hemost ISSN： 1076-0296 Impact factor: 2.389