Literature DB >> 15094497

Adenovirus-mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury.

Xiao-Qing Tang1, Yun Wang, Zhi-Hua Huang, Ji-Sheng Han, You Wan.   

Abstract

The aim of the present study was to assess the effect of glial cell line-derived neurotrophic factor (GDNF) delivery mediated by a recombinant adenovirus (AdCMVgdnf or AdCMVlacZ) on the functional recovery and central neuronal atrophy in adult rats with spinal cord injury. Bilateral electrolytic lesions were made in the corticospinal tracts at the T10 vertebral level in a rat model. AdCMVgdnf or AdCMVlacZ was injected at the lesion site immediately after operation. After 2-3 weeks the neurological score and the inclined plane angle were significantly higher and the soma size of corticospinal motoneurons was larger in the AdCMVgdnf group compared with the AdCMVlacZ group. These results demonstrated that adenovirus-mediated delivery of GDNF could prevent the retrograde atrophy of corticospinal motoneurons and improve the motor function in rats with spinal cord injury. Copyright 2004 Lippincott Williams & Wilkins

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Year:  2004        PMID： 15094497     DOI： 10.1097/00001756-200403010-00009

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

1.  Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal population.

Authors:  John E Greer; Melissa J McGinn; John T Povlishock
Journal:  J Neurosci       Date:  2011-03-30       Impact factor: 6.167

2.  Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury.

Authors:  Edmund R Hollis; Mark H Tuszynski
Journal:  Neurotherapeutics       Date:  2011-10       Impact factor: 7.620

3.  BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury.

Authors:  Masanori Sasaki; Christine Radtke; Andrew M Tan; Peng Zhao; Hirofumi Hamada; Kiyohiro Houkin; Osamu Honmou; Jeffery D Kocsis
Journal:  J Neurosci       Date:  2009-11-25       Impact factor: 6.167

4.  The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury.

Authors:  Lucy M Carter; Michelle L Starkey; Sonia F Akrimi; Meirion Davies; Stephen B McMahon; Elizabeth J Bradbury
Journal:  J Neurosci       Date:  2008-12-24       Impact factor: 6.167

5.  Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat.

Authors:  Y O Mukhamedshina; G F Shaymardanova; Е Е Garanina; I I Salafutdinov; А А Rizvanov; R R Islamov; Y A Chelyshev
Journal:  Spinal Cord       Date:  2015-09-29       Impact factor: 2.772

Review 6.  Corticospinal reorganization after spinal cord injury.

Authors:  Martin Oudega; Monica A Perez
Journal:  J Physiol       Date:  2012-05-14       Impact factor: 5.182

7.  Integrity of cortical perineuronal nets influences corticospinal tract plasticity after spinal cord injury.

Authors:  C Orlando; O Raineteau
Journal:  Brain Struct Funct       Date:  2014-01-31       Impact factor: 3.270

Review 8.  Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury.

Authors:  Anastasiia O Sosnovtseva; Olga V Stepanova; Aleksei A Stepanenko; Anastasia D Voronova; Andrey V Chadin; Marat P Valikhov; Vladimir P Chekhonin
Journal:  Front Pharmacol       Date:  2022-01-10       Impact factor: 5.810

9.  Newly developed TGF-β2 knock down transgenic mouse lines express TGF-β2 differently and its distribution in multiple tissues varies.

Authors:  Yan-Bin Xiyang; Fang Wang; Bao-Jiang Qian; Ling You; Bing-Tuan Lu; Wei Zhang; Xiong-Zhi Quan; Wen-Ping Ge; Su Liu; Lian-Feng Zhang; Ting-Hua Wang
Journal:  BMC Biochem       Date:  2013-08-06       Impact factor: 4.059

10.  Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury.

Authors:  Kyujin Hwang; Kwangsoo Jung; Il-Sun Kim; Miri Kim; Jungho Han; Joohee Lim; Jeong Eun Shin; Jae-Hyung Jang; Kook In Park
Journal:  Exp Neurobiol       Date:  2019-12-31       Impact factor: 3.261
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