Literature DB >> 15094366

CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes).

Dinesh Rakheja1, Srinivas B Narayan, Johanne V Pastor, Michael J Bennett.   

Abstract

Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.

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Year:  2004        PMID： 15094366     DOI： 10.1016/j.bbrc.2004.03.146

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses.

Authors:  Sara E Mole; Ruth E Williams; Hans H Goebel
Journal:  Neurogenetics       Date:  2005-09-28       Impact factor: 2.660

2.  Flunarizine rescues reduced lifespan in CLN3 triple knock-out Caenorhabditis elegans model of batten disease.

Authors:  Young Joon Kwon; Marni J Falk; Michael J Bennett
Journal:  J Inherit Metab Dis       Date:  2016-10-20       Impact factor: 4.982

3.  A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3(-/-) cells.

Authors:  Amanda L Getty; Jared W Benedict; David A Pearce
Journal:  Exp Cell Res       Date:  2010-09-17       Impact factor: 3.905

4.  The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking.

Authors:  Susan L Cotman; John F Staropoli
Journal:  Clin Lipidol       Date:  2012-02

5.  Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers.

Authors:  Kristina An Haack; Srinivas B Narayan; Haying Li; Ashley Warnock; Lu Tan; Michael J Bennett
Journal:  Biochim Biophys Acta       Date:  2010-10-07

6.  A novel role of the Batten disease gene CLN3: association with BMP synthesis.

Authors:  Judith A Hobert; Glyn Dawson
Journal:  Biochem Biophys Res Commun       Date:  2007-04-19       Impact factor: 3.575

7.  Phenotypic characterization of a mouse model of juvenile neuronal ceroid lipofuscinosis.

Authors:  Martin L Katz; Gary S Johnson; Gregory E Tullis; Bo Lei
Journal:  Neurobiol Dis       Date:  2007-09-07       Impact factor: 5.996

8.  btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.

Authors:  Sandra Codlin; Rebecca L Haines; Sara E Mole
Journal:  Traffic       Date:  2008-03-10       Impact factor: 6.215

9.  RNAi-mediated knockdown of the CLN3 gene inhibits proliferation and promotes apoptosis in drug-resistant ovarian cancer cells.

Authors:  Dongwei Mao; Jianhua Che; Shiyu Han; Honghui Zhao; Yumei Zhu; Hong Zhu
Journal:  Mol Med Rep       Date:  2015-08-21       Impact factor: 2.952
  9 in total

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