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Literature DB >> 15094114

Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family.

Abstract

Hevin is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. Hevin is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis.

Entities: Disease Gene

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Year: 2004 PMID： 15094114 DOI： 10.1016/j.biocel.2004.01.017

Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085

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Cited

38 in total

1. Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis.

Authors: Thomas H Barker; Paul Framson; Pauli A Puolakkainen; May Reed; Sarah E Funk; E Helene Sage
Journal: Am J Pathol Date: 2005-03 Impact factor: 4.307

Review 2. Matricellular proteins and biomaterials.

Authors: Aaron H Morris; Themis R Kyriakides
Journal: Matrix Biol Date: 2014-03-20 Impact factor: 11.583

3. Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.

Authors: Anna M Zawadzka; Birgit Schilling; Jason M Held; Alexandria K Sahu; Michael P Cusack; Penelope M Drake; Susan J Fisher; Bradford W Gibson
Journal: Electrophoresis Date: 2014-07-10 Impact factor: 3.535

4. SPARCL1: a potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer.

Authors: Hong Zhang; Emma Widegren; Da-Wei Wang; Xiao-Feng Sun
Journal: Tumour Biol Date: 2011-09-02

5. Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.

Authors: Matt Weaver; Gail Workman; Chad R Schultz; Nancy Lemke; Sandra A Rempel; E Helene Sage
Journal: J Cell Biochem Date: 2011-11 Impact factor: 4.429

Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family.

1. Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis.

Review 2. Matricellular proteins and biomaterials.

3. Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.

4. SPARCL1: a potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer.

5. Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.

6. Effect of hevin deletion in mice and characterization in trabecular meshwork.

7. A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system.

8. Differences in gene expression profiles from asbestos-treated SPARC-null and wild-type mouse lungs.

9. Microarray-based cancer prediction using soft computing approach.

10. The role of SPARC in extracellular matrix assembly.