PURPOSE: Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed. METHODS AND MATERIALS: Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease. RESULTS: After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was noted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion. CONCLUSION: Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique.
PURPOSE: Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed. METHODS AND MATERIALS: Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease. RESULTS: After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was noted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion. CONCLUSION: Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique.
Authors: Chaitanyanand B Koppiker; Aijaz Ul Noor; Santosh Dixit; Laleh Busheri; Gautam Sharan; Upendra Dhar; Hari Kiran Allampati; Smeeta Nare Journal: Int J Breast Cancer Date: 2019-02-20
Authors: Z E Winters; J Horsnell; K T Elvers; A J Maxwell; L J Jones; A M Shaaban; P Schmid; N R Williams; A Beswick; R Greenwood; J C Ingram; C Saunders; J S Vaidya; L Esserman; I Jatoi; A M Brunt Journal: BJS Open Date: 2018-05-22