OBJECTIVES: We studied the safety and efficacy of atrial flutter (AFL) ablation using 8- or 10-mm electrode catheters and a 100-W radiofrequency (RF) generator. BACKGROUND: Large-tip electrode catheters may be more effective for ablation of AFL. METHODS: There were 169 patients (age 61 +/- 12 years). Short-term end points were bidirectional isthmus block and no inducible AFL. After ablation, patients were seen at one, three, and six months, with event monitoring performed weekly and for any symptoms. Three quality-of-life (QOL) surveys were completed during follow-up. RESULTS: Short-term success was achieved in 158 patients (93%), with 12 +/- 11 RF applications. The efficacy of 8- and 10-mm electrodes was similar (p = NS). The number of RF applications (10 +/- 8 vs. 14 +/- 8) and ablation time (0.5 +/- 0.4 h vs. 0.8 +/- 0.6 h) were less with the 10- versus 8-mm electrode, respectively (p < 0.01). Of 158 patients with short-term success, 42 patients were not evaluated for success at six months because of study exclusions. Of 116 patients with short-term success evaluated at six months, 112 (97%) patients had no AFL recurrence. Of those without AFL recurrence at six months, 95% and 93% remained free of symptoms at 12 and 24 months, respectively. Ablation of AFL improved QOL scores (p < 0.05) and reduced anti-arrhythmic and rate-control drug use (p < 0.05). Complications occurred in 6 (3.6%) of 169 patients, but there were no deaths. CONCLUSIONS: Ablation of AFL with 8- or 10-mm electrode catheters and a high-power RF generator was safe and effective and improved QOL. The number and duration of RF applications were lower with 10- versus 8-mm electrode catheters.
OBJECTIVES: We studied the safety and efficacy of atrial flutter (AFL) ablation using 8- or 10-mm electrode catheters and a 100-W radiofrequency (RF) generator. BACKGROUND: Large-tip electrode catheters may be more effective for ablation of AFL. METHODS: There were 169 patients (age 61 +/- 12 years). Short-term end points were bidirectional isthmus block and no inducible AFL. After ablation, patients were seen at one, three, and six months, with event monitoring performed weekly and for any symptoms. Three quality-of-life (QOL) surveys were completed during follow-up. RESULTS: Short-term success was achieved in 158 patients (93%), with 12 +/- 11 RF applications. The efficacy of 8- and 10-mm electrodes was similar (p = NS). The number of RF applications (10 +/- 8 vs. 14 +/- 8) and ablation time (0.5 +/- 0.4 h vs. 0.8 +/- 0.6 h) were less with the 10- versus 8-mm electrode, respectively (p < 0.01). Of 158 patients with short-term success, 42 patients were not evaluated for success at six months because of study exclusions. Of 116 patients with short-term success evaluated at six months, 112 (97%) patients had no AFL recurrence. Of those without AFL recurrence at six months, 95% and 93% remained free of symptoms at 12 and 24 months, respectively. Ablation of AFL improved QOL scores (p < 0.05) and reduced anti-arrhythmic and rate-control drug use (p < 0.05). Complications occurred in 6 (3.6%) of 169 patients, but there were no deaths. CONCLUSIONS: Ablation of AFL with 8- or 10-mm electrode catheters and a high-power RF generator was safe and effective and improved QOL. The number and duration of RF applications were lower with 10- versus 8-mm electrode catheters.
Authors: Miki Yokokawa; Mohamad C Sinno; Mohammed Saeed; Rakesh Latchamsetty; Hamid Ghanbari; Thomas Crawford; Krit Jongnarangsin; Ryan Cunnane; Frank Pelosi; Frank Bogun; Aman Chugh; Fred Morady; Hakan Oral Journal: J Interv Card Electrophysiol Date: 2018-05-11 Impact factor: 1.900
Authors: Javier García Seara; Francisco Gude; Pilar Cabanas; José L Martínez-Sande; Xesús Fernández López; Antonio Hernández Madrid; Concepción Moro; José R González Juanatey Journal: Health Qual Life Outcomes Date: 2012-08-06 Impact factor: 3.186
Authors: Xiaoqiang Qi; Guangfu Li; Dai Liu; Anjan Motamarry; Xiangwei Huang; A Marissa Wolfe; Kristi L Helke; Dieter Haemmerich; Kevin F Staveley-O'Carroll; Eric T Kimchi Journal: Cancer Biol Ther Date: 2015 Impact factor: 4.875