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Literature DB >> 15091336

Quickening the pace: looking into the heart of HCN channels.

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to a wide range of physiological functions and regulate cardiac and neuronal pacemaker activity. Here, we review recent advances in three areas: the polarity of the S4 movement with hyperpolarization, the location of the activation gate, and the structure of the C-terminal C linker and CNBD.

Entities: Chemical

Mesh：

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Year: 2004 PMID： 15091336 DOI： 10.1016/s0896-6273(04)00199-0

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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Cited

10 in total

1. The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.

Authors: J P Johnson; William N Zagotta
Journal: Proc Natl Acad Sci U S A Date: 2005-02-14 Impact factor: 11.205

2. The role of allosteric coupling on thermal activation of thermo-TRP channels.

Authors: Andrés Jara-Oseguera; León D Islas
Journal: Biophys J Date: 2013-05-21 Impact factor: 4.033

3. cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.

Authors: Marco Berrera; Sergio Pantano; Paolo Carloni
Journal: Biophys J Date: 2006-02-24 Impact factor: 4.033

4. Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.

Authors: Bryan VanSchouwen; Madoka Akimoto; Maryam Sayadi; Federico Fogolari; Giuseppe Melacini
Journal: J Biol Chem Date: 2015-05-04 Impact factor: 5.157

Quickening the pace: looking into the heart of HCN channels.

1. The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.

2. The role of allosteric coupling on thermal activation of thermo-TRP channels.

3. cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.

4. Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.

5. Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex.

6. Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels.

7. Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.

8. Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage.

9. Ion channel structure and the promise of bacteria: cyclic nucleotide-gated channels in the queue.

10. cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.