OBJECTIVE: To estimate the effect of HIV-1 infection on subsequent mortality in a complete population. DESIGN: Prospective cohort study. SUBJECTS: A total of 7250 haemophilic males were registered in the UK Haemophilia Centre Doctors' Organisation database, 1977-1998. Most were infected with hepatitis C virus. In the early 1980s, 1246 were infected with HIV-1 from contaminated clotting factor concentrate. The main outcome measure was the date of death. RESULTS: During 1977-1984 annual mortality in severely haemophilic males was 0.9%. For those with HIV, annual mortality increased progressively from 1985 reaching over 10% during 1993-1996 before falling to 5% in 1997-1999, whereas without HIV it remained approximately 0.9% throughout 1985-1999. For moderately/mildly haemophilic males the annual mortality was 0.4% during 1977-1984. Without HIV it remained approximately 0.4% throughout 1985-1999, but with HIV it was similar to that in severe haemophilia with HIV. Survival was strongly related to age at HIV infection. The large temporal changes in mortality with HIV were largely accounted for by HIV-related conditions. Without HIV annual liver disease mortality remained below 0.2% throughout 1985-1999, but with HIV it was 0.2% during 1985-1990, 0.8% during 1991-1996, and 0.8% during 1997-1999. CONCLUSION: These data provide a direct estimate of the effect of HIV-1 infection on subsequent mortality in a population with a high prevalence of hepatitis C. From approximately 3 years after HIV infection, large, progressive increases in mortality were seen. From 1997, after the introduction of effective treatment, substantial reductions occurred, although mortality from liver disease remained high.
OBJECTIVE: To estimate the effect of HIV-1 infection on subsequent mortality in a complete population. DESIGN: Prospective cohort study. SUBJECTS: A total of 7250 haemophilic males were registered in the UK Haemophilia Centre Doctors' Organisation database, 1977-1998. Most were infected with hepatitis C virus. In the early 1980s, 1246 were infected with HIV-1 from contaminated clotting factor concentrate. The main outcome measure was the date of death. RESULTS: During 1977-1984 annual mortality in severely haemophilic males was 0.9%. For those with HIV, annual mortality increased progressively from 1985 reaching over 10% during 1993-1996 before falling to 5% in 1997-1999, whereas without HIV it remained approximately 0.9% throughout 1985-1999. For moderately/mildly haemophilic males the annual mortality was 0.4% during 1977-1984. Without HIV it remained approximately 0.4% throughout 1985-1999, but with HIV it was similar to that in severe haemophilia with HIV. Survival was strongly related to age at HIV infection. The large temporal changes in mortality with HIV were largely accounted for by HIV-related conditions. Without HIV annual liver disease mortality remained below 0.2% throughout 1985-1999, but with HIV it was 0.2% during 1985-1990, 0.8% during 1991-1996, and 0.8% during 1997-1999. CONCLUSION: These data provide a direct estimate of the effect of HIV-1 infection on subsequent mortality in a population with a high prevalence of hepatitis C. From approximately 3 years after HIV infection, large, progressive increases in mortality were seen. From 1997, after the introduction of effective treatment, substantial reductions occurred, although mortality from liver disease remained high.
Authors: Giovanni Di Minno; Mariana Canaro; James W Ironside; David Navarro; Carlo Federico Perno; Andreas Tiede; Lutz Gürtler Journal: Haematologica Date: 2013-10 Impact factor: 9.941
Authors: Jérôme Lane; Paul J McLaren; Lucy Dorrell; Kevin V Shianna; Amanda Stemke; Kimberly Pelak; Stephen Moore; Johannes Oldenburg; Maria Teresa Alvarez-Roman; Anne Angelillo-Scherrer; Francoise Boehlen; Paula H B Bolton-Maggs; Brigit Brand; Deborah Brown; Elaine Chiang; Ana Rosa Cid-Haro; Bonaventura Clotet; Peter Collins; Sara Colombo; Judith Dalmau; Patrick Fogarty; Paul Giangrande; Alessandro Gringeri; Rathi Iyer; Olga Katsarou; Christine Kempton; Philip Kuriakose; Judith Lin; Mike Makris; Marilyn Manco-Johnson; Dimitrios A Tsakiris; Javier Martinez-Picado; Evelien Mauser-Bunschoten; Anne Neff; Shinichi Oka; Lara Oyesiku; Rafael Parra; Kristiina Peter-Salonen; Jerry Powell; Michael Recht; Amy Shapiro; Kimo Stine; Katherine Talks; Amalio Telenti; Jonathan Wilde; Thynn Thynn Yee; Steven M Wolinsky; Jeremy Martinson; Shehnaz K Hussain; Jay H Bream; Lisa P Jacobson; Mary Carrington; James J Goedert; Barton F Haynes; Andrew J McMichael; David B Goldstein; Jacques Fellay Journal: Hum Mol Genet Date: 2013-01-30 Impact factor: 6.150
Authors: Flora Peyvandi; Johnny N Mahlangu; Steven W Pipe; Charles R M Hay; Glenn F Pierce; Peter Kuebler; Rebecca Kruse-Jarres; Midori Shima Journal: J Thromb Haemost Date: 2021-01 Impact factor: 5.824