OBJECTIVE: Bilateral and multiple lymphoepithelial cysts (LECs) of major salivary glands, in particular of parotid glands, are quite rare and have been reported in human immunodeficiency virus (HIV) infected patients with an incidence of about 3-6%. These lesions represent an early manifestation of HIV infection and are rarely found in patients with advanced acquired immunodeficiency syndrome. MATERIALS: Two cases of parotid LECs, the first occurring in a middle-age white woman and the second in a young white boy, both in advanced phases of HIV infection, are reported. RESULTS: Clinical, cytological, histological and immunohistochemical (cytokeratin AE1/AE3, CD20, CD45RA, CD8, kappa and lambda immunoglobulin light chains, S-100, MLA and Ki67) features are described. CONCLUSIONS: Fine needle aspiration (FNA), a relatively non-traumatic procedure, could represent both a diagnostic and a therapeutic tool in parotid LECs. No surgical therapy is usually required for these lesions and aspiration of cystic fluid with FNA is quite resolutive, although evidence of further relapses does exist. Surgical excision may become necessary when pain, because of persistent and progressive swelling of the parotid gland, occurs.
OBJECTIVE: Bilateral and multiple lymphoepithelial cysts (LECs) of major salivary glands, in particular of parotid glands, are quite rare and have been reported in human immunodeficiency virus (HIV) infectedpatients with an incidence of about 3-6%. These lesions represent an early manifestation of HIV infection and are rarely found in patients with advanced acquired immunodeficiency syndrome. MATERIALS: Two cases of parotid LECs, the first occurring in a middle-age white woman and the second in a young white boy, both in advanced phases of HIV infection, are reported. RESULTS: Clinical, cytological, histological and immunohistochemical (cytokeratin AE1/AE3, CD20, CD45RA, CD8, kappa and lambda immunoglobulin light chains, S-100, MLA and Ki67) features are described. CONCLUSIONS: Fine needle aspiration (FNA), a relatively non-traumatic procedure, could represent both a diagnostic and a therapeutic tool in parotid LECs. No surgical therapy is usually required for these lesions and aspiration of cystic fluid with FNA is quite resolutive, although evidence of further relapses does exist. Surgical excision may become necessary when pain, because of persistent and progressive swelling of the parotid gland, occurs.
Authors: Waleed F Mourad; Shyamal Patel; Rebekah Young; Azita S Khorsandi; Catherine Concert; Rania A Shourbaji; Katherine Ciarrocca; Richard L Bakst; Daniel Shasha; Chandan Guha; Madhur K Garg; Kenneth S Hu; Shalom Kalnicki; Louis B Harrison Journal: Eur Arch Otorhinolaryngol Date: 2016-02-16 Impact factor: 2.503
Authors: John Lennon Silva Cunha; Ana Luiza Oliveira Corrêa Roza; Vitória Maria Sousa Cruz; Jaqueline Lemes Ribeiro; Israel Leal Cavalcante; Roberta Barroso Cavalcante; Ana Lia Anbinder; Aline Corrêa Abrahão; Bruno Augusto Benevenuto de Andrade; Mário José Romañach; Fábio Ramôa Pires; Alan Roger Dos Santos-Silva; Márcio Ajudarte Lopes; Pablo Agustin Vargas; Ciro Dantas Soares; Oslei Paes de Almeida Journal: Head Neck Pathol Date: 2021-06-29